NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 23782 / LMG 2373 / NCIB 11773 / SB1003 / St. Louis;
PubMed=9256491 [NCBI, ExPASy, EBI, Israel, Japan]
Vlcek C., Paces V., Maltsev N., Paces J., Haselkorn R., Fonstein M.;
"Sequence of a 189-kb segment of the chromosome of Rhodobacter capsulatus SB1003.";
Proc. Natl. Acad. Sci. U.S.A. 94:9384-9388(1997).

Comments

FUNCTION: Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y.
CATALYTIC ACTIVITY: Precorrin-6B + NADP⁺ = precorrin-6A + NADPH.
PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinic acid a,c-diamide from precorrin-2 (aerobic route): step 6/10 .
SIMILARITY: Belongs to the precorrin-6x reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF010496; AAC16188.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

T03535; T03535.

3D structure databases

ModBase

O68098.

Ontologies

GO:0016994;	Molecular function: precorrin-6A reductase activity (inferred from electronic annotation from InterPro).
GO:0009236;	Biological process: cobalamin biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR003723; Cbl_synth_CobK/CbiJ.
Graphical view of domain structure.

Pfam

PF02571; CbiJ; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00715; precor6x_red; 1.

PROSITE

PS51014; COBK_CBIJ; 1.
PROSITE graphical view of domain structure (profiles).

Other

ProtoNet

O68098.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cobalamin biosynthesis; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 251`	`251`		`Precorrin-6A reductase.`	`PRO_0000135921`

Sequence information

Length: 251 AA [This is the length of the unprocessed precursor]

Molecular weight: 26048 Da [This is the MW of the unprocessed precursor]

CRC64: 877B825031DB202F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTRLLVLGGT TEASRLAKTL ADQGFEAVFS YAGRTGAPVA QPLPTRIGGF GGVAGLVDYL 

        70         80         90        100        110        120 
TREGVSHVID ATHPFAAQMS ANAVAACAQT GVALCAFERA PWTAQAGDRW THVPDLAAAV 

       130        140        150        160        170        180 
AALPQAPARV FLAIGKQHLR DFSAAPQHHY LLRLVDPPEG PLPLPDARAV IARGPFTVQG 

       190        200        210        220        230        240 
DTELLRSETI THVVAKNAGG AGAEAKLIAA RSLGLPVILI DRPAVPARDI CATLEGVMGW 

       250 
LADHGATPRG V

O68098 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools