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UniProtKB/Swiss-Prot entry O67289

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ILVC_AQUAE
Primary accession number O67289
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 57)
Name and origin of the protein
Protein name Ketol-acid reductoisomerase
Synonyms EC 1.1.1.86
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene name
Name: ilvC
OrderedLocusNames: aq_1245
From
Aquifex aeolicus [TaxID: 63363] [HAMAP proteome]
Taxonomy Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=VF5;
DOI=10.1038/32831; PubMed=9537320 [NCBI, ExPASy, EBI, Israel, Japan]
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
Nature 392:353-358(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000657; AAC07240.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F70407; F70407.
RefSeq NP_213853.1; -.
3D structure databases
HSSP Q9HVA2; 1NP3. [HSSP ENTRY / PDB]
ModBase O67289.
Enzyme and pathway databases
BioCyc AAEO224324:AQ_1245-MON; -.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004455; Molecular function: ketol-acid reductoisomerase activity (inferred from electronic annotation from HAMAP).
GO:0009097; Biological process: isoleucine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0009099; Biological process: valine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00435; -; 1.
PBIL [Tree]
InterPro IPR013023; AcH_isomrdctse.
IPR000506; AcH_isomrdctse_C.
IPR013116; IlvN.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR21371; AcH_isomrdctse; 1.
Pfam PF01450; IlvC; 1.
PF07991; IlvN; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00465; ilvC; 1.
Genome annotation databases
GeneID 1192727; -.
GenomeReviews AE000657_GR; aq_1245.
KEGG aae:aq_1245; -.
NMPDR fig|224324.1.peg.868; -.
Phylogenomic databases
HOGENOM O67289; -.
Genome annotation databases
CMR O67289; aq_1245.
Other
ProtoNet O67289.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   333  333     Ketol-acid reductoisomerase. PRO_0000151269
ACT_SITE   108   108        Potential. 
Sequence information
Length: 333 AA [This is the length of the unprocessed precursor] Molecular weight: 37307 Da [This is the MW of the unprocessed precursor] CRC64: 8E55F82619698B55 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAKIYYDEDA SLDILKDKVI AILGYGSQGH AHALNLRDSG LNVIIGLHEG SRSREKAKAD 

        70         80         90        100        110        120 
GFEVYTPREA AKRADIIMFL IPDTVQPEVY KNEVEPELNS SKTLAFAHGF NIHFRQIVPP 

       130        140        150        160        170        180 
KDVDVFMVAP KGPGHLVRWM YTEGKGVPAL VAIHQDASGT CKDKALAYAK GIGATRAGVI 

       190        200        210        220        230        240 
ETTFKEETET DLFGEQMVLC GGVTALIKAG FETLVNAGYQ PEVAYFECLH ELKLIVDLIY 

       250        260        270        280        290        300 
EHGISGMRYS ISDTAKYGDV TRGERIYKVV KPVMEKTLEE IQKGEFAREW ILENKAGRPV 

       310        320        330 
YYALLERDRE HLVEKVGEEL RKMMPWLGKK ELK
O67289 in FASTA format

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