NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=VF5;
DOI=10.1038/32831; PubMed=9537320 [NCBI, ExPASy, EBI, Israel, Japan]
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
Nature 392:353-358(1998).

Comments

CATALYTIC ACTIVITY: ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 1/4 .
PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3 .
PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5 .
SIMILARITY: Belongs to the aspartokinase family.
SIMILARITY: Contains 2 ACT domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE000657; AAC07182.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

B70399; B70399.

RefSeq

NP_213785.1; -.

3D structure databases

ModBase

O67221.

Enzyme and pathway databases

BioCyc

AAEO224324:AQ_1152-MON; -.

Ontologies

GO:0016597;	Molecular function: amino acid binding (inferred from electronic annotation from InterPro).
GO:0004072;	Molecular function: aspartate kinase activity (inferred from electronic annotation from InterPro).
GO:0019877;	Biological process: diaminopimelate biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002912; ACT_bd.
IPR001048; Asp/Glu/Uridylate_kinase.
IPR005260; Asp_kin_monofn.
IPR001341; Asp_kin_reg.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.1160.10; Aa_kinase; 1.

Pfam

PF00696; AA_kinase; 1.
PF01842; ACT; 2.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00656; asp_kin_monofn; 1.
TIGR00657; asp_kinases; 1.

PROSITE

PS00324; ASPARTOKINASE; 1.

Genome annotation databases

GeneID

1192567; -.

GenomeReviews

AE000657_GR; aq_1152.

KEGG

aae:aq_1152; -.

NMPDR

fig|224324.1.peg.800; -.

Phylogenomic databases

HOGENOM

O67221; -.

Genome annotation databases

CMR

O67221; aq_1152.

Other

ProtoNet

O67221.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Diaminopimelate biosynthesis; Kinase; Lysine biosynthesis; Repeat; Transferase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 415`	`415`	`Aspartokinase.`	`PRO_0000066671`
`DOMAIN`	`262 335`	`74`	`ACT 1.`
`DOMAIN`	`342 405`	`64`	`ACT 2.`

Sequence information

Length: 415 AA [This is the length of the unprocessed precursor]

Molecular weight: 45519 Da [This is the MW of the unprocessed precursor]

CRC64: E8111750A8C14162 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKILVQKFGG TSVGTLERIE LCAKRVIKAL EKGYKPVVVS SAMAGETDSL IELAKKVHPR 

        70         80         90        100        110        120 
PPEREMDTLL AVGEQKAIAL FAMTLNKLGY PAVSLCGWQV PIITDNVHTK ARIRKIGISR 

       130        140        150        160        170        180 
LLSLIEEGYI PVVAGFQGVT EDWEITTLGR GGSDTTAVAL AAALKADCEI NTDVPGVFTA 

       190        200        210        220        230        240 
DPRIVPNAKK IKKISYEEML ELASLGAKVM QIRSVEFAAK YNVRIHVRST FSEEEGTWIV 

       250        260        270        280        290        300 
PEDEVMEKVA VRGITVDTKE TRFTVVRVPD KPGIAAEIFK ALGDAHIVVD MIVQNVSHEG 

       310        320        330        340        350        360 
YTDMSFTVNK TDADKAEEIV KKIAQKIGAK EVVRDDKVAK ISIVGIGMKS AYGVAGRMFD 

       370        380        390        400        410 
ILARNGINIK AISTSEIKIS CLIDEKYAEL AVRALHEEFI EEMEEFETIN GKNKE

O67221 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools