NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=VF5;
DOI=10.1038/32831; PubMed=9537320 [NCBI, ExPASy, EBI, Israel, Japan]
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
Nature 392:353-358(1998).

[2]

X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
DOI=10.1038/43710; PubMed=10490031 [NCBI, ExPASy, EBI, Israel, Japan]
Finnin M.S., Donigian J.R., Cohen A., Richon V.M., Rifkind R.A., Marks P.A., Breslow R., Pavletich N.P.;
"Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.";
Nature 401:188-193(1999).

Comments

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE000657; AAC07100.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

D70388; D70388.

RefSeq

NP_213698.1; -.

3D structure databases

PDB

1C3P; X-ray; 1.80 A; A=1-375.	[ExPASy / RCSB / EBI]
1C3R; X-ray; 2.00 A; A/B=1-375.	[ExPASy / RCSB / EBI]
1C3S; X-ray; 2.50 A; A=1-375.	[ExPASy / RCSB / EBI]

Detailed list of linked structures.

PDBsum

1C3P; -.
1C3R; -.
1C3S; -.

ModBase

O67135.

Enzyme and pathway databases

BioCyc

AAEO224324:AQ_1023-MON; -.

Ontologies

GO:0005634;	Cellular component: nucleus (inferred from electronic annotation from InterPro).
GO:0004407;	Molecular function: histone deacetylase activity (inferred from electronic annotation from InterPro).
GO:0016575;	Biological process: histone deacetylation (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000286; His_deacetylse.
IPR003084; His_deacetylse_1.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.800.20; His_deacetylse; 1.

PANTHER

PTHR10625; His_deacetylse; 1.

Pfam

PF00850; Hist_deacetyl; 1.
Pfam graphical view of domain structure.

PRINTS

PR01270; HDASUPER.
PR01271; HISDACETLASE.

Genome annotation databases

GeneID

1193769; -.

GenomeReviews

AE000657_GR; aq_1023.

KEGG

aae:aq_1023; -.

NMPDR

fig|224324.1.peg.713; -.

Phylogenomic databases

HOGENOM

O67135; -.

Genome annotation databases

CMR

O67135; aq_1023.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome.

Features

None

Sequence information

Length: 375 AA

Molecular weight: 42663 Da

CRC64: 0A7117BC823403DF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKKVKLIGTL DYGKYRYPKN HPLKIPRVSL LLRFLDAMNL IDEKELIKSR PATKEELLLF 

        70         80         90        100        110        120 
HTEDYINTLM EAERCQCVPK GAREKYNIGG YENPVSYAMF TGSSLATGST VQAIEEFLKG 

       130        140        150        160        170        180 
NVAFNPAGGM HHAFKSRANG FCYINDPAVG IEYLRKKGFK RILYIDLDAH HCDGVQEAFY 

       190        200        210        220        230        240 
DTDQVFVLSL HQSPEYAFPF EKGFLEEIGE GKGKGYNLNI PLPKGLNDNE FLFALEKSLE 

       250        260        270        280        290        300 
IVKEVFEPEV YLLQLGTDPL LEDYLSKFNL SNVAFLKAFN IVREVFGEGV YLGGGGYHPY 

       310        320        330        340        350        360 
ALARAWTLIW CELSGREVPE KLNNKAKELL KSIDFEEFDD EVDRSYMLET LKDPWRGGEV 

       370 
RKEVKDTLEK AKASS

O67135 in FASTA format

View entry in original UniProtKB/TrEMBL format
View entry in raw text format (no links)
Request for annotation of this UniProtKB/TrEMBL entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools