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UniProtKB/Swiss-Prot entry O67049

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AROE_AQUAE
Primary accession number O67049
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 59)
Name and origin of the protein
Protein name Shikimate dehydrogenase
Synonym EC 1.1.1.25
Gene name
Name: aroE
OrderedLocusNames: aq_901
From
Aquifex aeolicus [TaxID: 63363] [HAMAP proteome]
Taxonomy Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=VF5;
DOI=10.1038/32831; PubMed=9537320 [NCBI, ExPASy, EBI, Israel, Japan]
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
Nature 392:353-358(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000657; AAC07007.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F70377; F70377.
RefSeq NP_213611.1; -.
3D structure databases
PDB
2HK7; X-ray; 2.50 A; A/B=1-269.[ExPASy / RCSB / EBI]
2HK8; X-ray; 2.35 A; A/B/C/D/E/F/G/H=1-269.[ExPASy / RCSB / EBI]
2HK9; X-ray; 2.20 A; A/B/C/D=1-269.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 2HK7; -.
2HK8; -.
2HK9; -.
ModBase O67049.
Enzyme and pathway databases
BioCyc AAEO224324:AQ_901-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0004764; Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073; Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00222; -; 1.
PBIL [Tree]
InterPro IPR011342; Quinate/shikimate_5-DHase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.
Pfam PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00507; aroE; 1.
Genome annotation databases
GeneID 1193591; -.
GenomeReviews AE000657_GR; aq_901.
KEGG aae:aq_901; -.
NMPDR fig|224324.1.peg.626; -.
Phylogenomic databases
HOGENOM O67049; -.
Genome annotation databases
CMR O67049; aq_901.
Other
ProtoNet O67049.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   269  269     Shikimate dehydrogenase. PRO_0000135990
NP_BIND   130   134  5     NADP (By similarity). 
ACT_SITE   70    70        Proton acceptor (Potential). 
Sequence information
Length: 269 AA [This is the length of the unprocessed precursor] Molecular weight: 30106 Da [This is the MW of the unprocessed precursor] CRC64: 3F2E5E490FB9ADB7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MINAQTQLYG VIGFPVKHSL SPVFQNALIR YAGLNAVYLA FEINPEELKK AFEGFKALKV 

        70         80         90        100        110        120 
KGINVTVPFK EEIIPLLDYV EDTAKEIGAV NTVKFENGKA YGYNTDWIGF LKSLKSLIPE 

       130        140        150        160        170        180 
VKEKSILVLG AGGASRAVIY ALVKEGAKVF LWNRTKEKAI KLAQKFPLEV VNSPEEVIDK 

       190        200        210        220        230        240 
VQVIVNTTSV GLKDKDPEIF NYDLIKKDHV VVDIIYKETK LLKKAKEKGA KLFDGLPMLL 

       250        260 
WQGIEAFKIW NGCEVPYSVA ERSVRDLRG
O67049 in FASTA format

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