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UniProtKB/Swiss-Prot entry O65992

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MTLD_CLOAB
Primary accession number O65992
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 53)
Name and origin of the protein
Protein name Mannitol-1-phosphate 5-dehydrogenase
Synonym EC 1.1.1.17
Gene name
Name: mtlD
OrderedLocusNames: CA_C0157
From
Clostridium acetobutylicum [TaxID: 1488] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
PubMed=11160802 [NCBI, ExPASy, EBI, Israel, Japan]
Behrens S., Mitchell W.J., Bahl H.;
"Molecular analysis of the mannitol operon of Clostridium acetobutylicum encoding a phosphotransferase system and a putative PTS-modulated regulator.";
Microbiology 147:75-86(2001).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
DOI=10.1128/JB.183.16.4823-4838.2001; PubMed=11466286 [NCBI, ExPASy, EBI, Israel, Japan]
Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.;
"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum.";
J. Bacteriol. 183:4823-4838(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U53868; AAC12851.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE001437; AAK78141.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B96919; B96919.
RefSeq NP_346801.1; -.
3D structure databases
ModBase O65992.
Enzyme and pathway databases
BioCyc CACE272562:CAC0157-MON; -.
Ontologies
GO
GO:0050662; Molecular function: coenzyme binding (inferred from electronic annotation from InterPro).
GO:0008926; Molecular function: mannitol-1-phosphate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00196; -; 1.
PBIL [Tree]
InterPro IPR013328; DHase_multihelical.
IPR013118; Mannitol_DHase_C.
IPR000669; Mannitol_DHase_core.
IPR013131; Mannitol_DHase_N.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
Pfam PF01232; Mannitol_dh; 1.
PF08125; Mannitol_dh_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00084; MTLDHDRGNASE.
PROSITE PS00974; MANNITOL_DHGENASE; 1.
Genome annotation databases
GeneID 1116340; -.
GenomeReviews AE001437_GR; CA_C0157.
KEGG cac:CAC0157; -.
NMPDR fig|272562.1.peg.330; -.
Phylogenomic databases
HOGENOM O65992; -.
Genome annotation databases
CMR O65992; CA_C0157.
Other
ProtoNet O65992.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   384  384     Mannitol-1-phosphate 5-dehydrogenase. PRO_0000170702
NP_BIND   3    14  12     NAD (By similarity). 
Sequence information
Length: 384 AA [This is the length of the unprocessed precursor] Molecular weight: 43922 Da [This is the MW of the unprocessed precursor] CRC64: 0F73B98AFD9B8F6C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKALHFGAGN IGRGFIGYLL YKSNYETTFV DIFDKVVDDI NKYKRYTVIT LSTSKNKEKV 

        70         80         90        100        110        120 
ENVRAVNLKD SVALEKEVLE ADLITTSLGL NNLKSTGELL RGFLKKRSEI NDKPLDIIAC 

       130        140        150        160        170        180 
ENALFASDVL KKAILDGADE ELKKYLEKSV GFPNCTVDRI VPNVDIEKEL PIDVAVEDFY 

       190        200        210        220        230        240 
EWDIEKNKVK INNKIIGAEY VEKLDPYLER KLFLLNGAHA TIAYLGYLKG YKYIHEAIKD 

       250        260        270        280        290        300 
KEINKIIVGF HSEAVQALSE KHKIDIQILK EYSNKLLKRF ENEYLKDDVS RVGRDPMRKL 

       310        320        330        340        350        360 
SSNDRLITPL KLCCDLKIDF TNILFGVASG YLFNYKEDEK AQGIQNIITK EGIKKAISNV 

       370        380 
SQIKEGDYLN NMIAYKYEEL KKQN
O65992 in FASTA format

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