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UniProtKB/Swiss-Prot entry O62768

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TRXR1_BOVIN
Primary accession number O62768
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on February 26, 2008 (Sequence version 3)
Annotations were last modified on    December 16, 2008 (Entry version 73)
Name and origin of the protein
Protein name Thioredoxin reductase 1, cytoplasmic
Synonyms TR
EC 1.8.1.9
Thioredoxin reductase TR1
Gene name
Name: TXNRD1
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Small intestine;
Terashima H.;
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF053984; AAC13914.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_777050.1; -.
UniGene Bt.5534
3D structure databases
HSSP Q94655; 1ONF. [HSSP ENTRY / PDB]
SMR O62768; 11-493.
ModBase O62768.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0016654; Molecular function: oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor (inferred from electronic annotation from InterPro).
GO:0008430; Molecular function: selenium binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004791; Molecular function: thioredoxin-disulfide reductase activity (inferred from electronic annotation from EC).
GO:0045454; Biological process: cell redox homeostasis (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR000815; Hg_reductase.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
IPR012999; Pyr_OxRdtase_I_AS.
IPR001327; Pyr_OxRdtase_NAD_bd.
IPR006338; Reduct_Se.
Graphical view of domain structure.
Gene3D G3DSA:3.30.390.30; Pyr_redox_dim; 1.
PANTHER PTHR22912:SF23; Reduct_Se; 1.
Pfam PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
PF02852; Pyr_redox_dim; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
PR00945; HGRDTASE.
PR00411; PNDRDTASEI.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01438; TGR; 1.
PROSITE PS00076; PYRIDINE_REDOX_1; 1.
Genome annotation databases
Ensembl ENSBTAG00000013912; Bos taurus. [Contig view]
GeneID 282388; -.
KEGG bta:282388; -.
Phylogenomic databases
HOVERGEN O62768; -.
Other
ProtoNet O62768.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; FAD; Flavoprotein; NADP; Oxidoreductase; Phosphoprotein; Redox-active center; Selenium; Selenocysteine.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   499  499     Thioredoxin reductase 1, cytoplasmic. PRO_0000067981
NP_BIND   42    59  18     FAD (By similarity). 
ACT_SITE   472   472        Proton acceptor (By similarity). 
NON_STD   498   498        Selenocysteine. 
MOD_RES   11    11        Phosphotyrosine (By similarity). 
MOD_RES   13    13        Phosphotyrosine (By similarity). 
MOD_RES   131   131        Phosphotyrosine (By similarity). 
MOD_RES   422   422        Phosphotyrosine (By similarity). 
DISULFID   59    64        Redox-active (By similarity). 
CROSSLNK   497   498        Cysteinyl-selenocysteine (Cys-Sec) (By similarity). 
Sequence information
Length: 499 AA [This is the length of the unprocessed precursor] Molecular weight: 54770 Da [This is the MW of the unprocessed precursor] CRC64: B0F15494D1795AB3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNGSKDLPEP YDYDLIIIGG GSGGLAAAKE AAKYDKKVMV LDFVTPTPLG TRWGLGGTCV 

        70         80         90        100        110        120 
NVGCIPKKLM HQAALLGQAL RDSRNYGWNV EETVKHDWER MTEAVQNHIG SLNWGYRVAL 

       130        140        150        160        170        180 
REKKVTYENA YGEFVGPHRI KATNNKGKEK IYSAERFLIA TGERPRYLGI PGDKEYCISS 

       190        200        210        220        230        240 
DDLFSLPYCP GKTLVVGASY VALECAGFLA GIGLDVTVMV RSILLRGFDQ DMANKIGEHM 

       250        260        270        280        290        300 
QEHGIKFIRQ FVPIKVEQIE AGTPGRLRVI AKSTDSDQTI EGEYNTVLLA IGRDACTRKI 

       310        320        330        340        350        360 
GLENVGVKIN EKTGKIPVTE EEQTNVPYIY AIGDILEGKL ELTPVAIQAG RLLAQRLYGG 

       370        380        390        400        410        420 
STVKCDYENV PTTVFTPLEY GSCGLSEEKA VEKFGEENVE VYHSYFWPLE WTIPSRDNNK 

       430        440        450        460        470        480 
CYAKVVCNIK DNERVVGFHV LGPNAGEVTQ GFAAALKCGL TKDQLDSTIG IHPVCAEVFT 

       490 
TLSVTKRSGG NILQTGCUG
O62768 in FASTA format

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