NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=9492393 [NCBI, ExPASy, EBI, Israel, Japan]
Blaisdell J., Goldstein J.A., Bai S.A.;
"Isolation of a new canine cytochrome P450 cDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression.";
Drug Metab. Dispos. 26:278-283(1998).

Comments

FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
CATALYTIC ACTIVITY: RH + reduced flavoprotein + O₂ = ROH + oxidized flavoprotein + H₂O.
COFACTOR: Heme group (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
INDUCTION: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
SIMILARITY: Belongs to the cytochrome P450 family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF016248; AAC08738.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001003334.1; -.

UniGene

Cfa.3499

3D structure databases

HSSP

P11712; 1OG2. [HSSP ENTRY / PDB]

SMR

O62671; 47-489.

ModBase

O62671.

Ontologies

GO:0005789;	Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005792;	Cellular component: microsome (inferred from electronic annotation from UniProtKB-KW).
GO:0009055;	Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0020037;	Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0050381;	Molecular function: unspecific monooxygenase activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.630.10; Cyt_P450; 1.

PANTHER

PTHR19383; Cyt_P450; 1.

Pfam

PF00067; p450; 1.
Pfam graphical view of domain structure.

PRINTS

PR00463; EP450I.
PR00385; P450.

PROSITE

PS00086; CYTOCHROME_P450; 1.

Genome annotation databases

GeneID

415123; -.

KEGG

cfa:415123; -.

Phylogenomic databases

HOVERGEN

O62671; -.

Other

ProtoNet

O62671.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 489`	`489`	`Cytochrome P450 2C41.`	`PRO_0000051724`
`METAL`	`434 434`		`Iron (heme axial ligand) (By similarity).`

Sequence information

Length: 489 AA [This is the length of the unprocessed precursor]

Molecular weight: 55499 Da [This is the MW of the unprocessed precursor]

CRC64: BDAA6739BAAA8E15 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDPVVVLVLC LSCCLLLSLW KQSSRKGKLP PGPTPLPFIG NILQLDKDIN KSLSNLSKAY 

        70         80         90        100        110        120 
GPVFTLYFGM KPTVVLHGYD AVKETLIDLG EEFSARGRFP IAEKVSGGHG IIFTSGNRWK 

       130        140        150        160        170        180 
EMRRFALTTL RNLGMGKSDL ESRVQEEACY LVEELRKTNA LPCDPTFVLG CASCNVICSI 

       190        200        210        220        230        240 
IFQNRFDYTD QTLIGFLEKL NENFRILSSP WIQAYNSFPA LLHYLPGSHN TIFKNFAFIK 

       250        260        270        280        290        300 
SYILEKIKEH QESFDVNNPR DFIDYFLIKM EQEKHNQPLE FTFENLKTIA TDLFGAGTET 

       310        320        330        340        350        360 
TSTTLRYGLL LLLKHPEVTV KVQEEIDRVI GRHQSPHMQD RSRMPYTNAV LHEIQRYIDL 

       370        380        390        400        410        420 
VPNSLPHAVT CDVKFRNYVI PKGTTILISL SSVLSDEKEF PRPEIFDPAH FLDDSGNFKK 

       430        440        450        460        470        480 
SDYFMAFSAG KRICVGEGLA RMELFLFLTT ILQKFTLKPL VDPKDIDTTP LASGFGHVPP 


TYQLCFIPV

O62671 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools