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UniProtKB/Swiss-Prot entry O61491


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FLOT1_DROME
Primary accession number O61491
Secondary accession number Q9V7D7
Integrated into Swiss-Prot on February 21, 2001
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 68)
Name and origin of the protein
Protein name Flotillin-1
Synonyms None
Gene name
Name: Flo
Synonyms: FLODM-1
ORFNames: CG8200
From
Drosophila melanogaster (Fruit fly) [TaxID: 7227] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), AND TISSUE SPECIFICITY.
DOI=10.1016/S0378-1119(98)00064-X; PubMed=9573373 [NCBI, ExPASy, EBI, Israel, Japan]
Galbiati F., Volonte D., Goltz J.S., Steele Z., Sen J., Jurcsak J., Stein D., Stevens L., Lisanti M.P.;
"Identification, sequence and developmental expression of invertebrate flotillins from Drosophila melanogaster.";
Gene 210:229-237(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3]
GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan]
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
STRAIN=Berkeley;
TISSUE=Embryo;
PubMed=12537569 [NCBI, ExPASy, EBI, Israel, Japan]
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF044734; AAC39012.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE013599; AAF58120.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE013599; AAF58121.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY058794; AAL14023.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_477358.1; -.
NP_725476.1; -.
UniGene Dm.2957
3D structure databases
ModBase O61491.
Protein-protein interaction databases
IntAct O61491; 1.
Enzyme and pathway databases
BioCyc DMEL-XXX-02:DMEL-XXX-02-004785-MON; -.
Organism-specific databases
FlyBase FBgn0024754; Flo.
Gene expression databases
ArrayExpress O61491; -.
GermOnline CG8200; Drosophila melanogaster.
Ontologies
GO
GO:0016600; Cellular component: flotillin complex (non-traceable author statement from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0005198; Molecular function: structural molecule activity (non-traceable author statement from UniProtKB).
GO:0007275; Biological process: multicellular organismal development (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001107; Band_7.
IPR004851; Flotillin.
Graphical view of domain structure.
Pfam PF01145; Band_7; 1.
PF03149; Flotillin; 1.
Pfam graphical view of domain structure.
SMART SM00244; PHB; 1.
SMART graphical view of domain structure.
Genome annotation databases
Ensembl CG8200; Drosophila melanogaster. [Contig view]
GeneID 36726; -.
KEGG dme:Dmel_CG8200; -.
Other
NextBio 800074; -.
ProtoNet O61491.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell membrane; Complete proteome; Developmental protein; Membrane.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   426  426     Flotillin-1. PRO_0000094054
VAR_SEQ   162   162        G -> GDSKG (in isoform Long). VSP_000506
Sequence information
Length: 426 AA [This is the length of the unprocessed precursor] Molecular weight: 47135 Da [This is the MW of the unprocessed precursor] CRC64: 64C99F9CB4676C0C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTWGFVTCGP NEALVVSGCC YMKPLLVPGG RAFVWPVGQQ VQRISLNTMT LQVESPCVYT 

        70         80         90        100        110        120 
SQGVPISVTG IAQVKVQGQN EDMLLTACEQ FLGKSEAEIN HIALVTLEGH QRAIMGSMTV 

       130        140        150        160        170        180 
EEIYKDRKKF SKQVFEVASS DLANMGITVV SYTIKDLRDE EGYLRSLGMA RTAEVKRDAR 

       190        200        210        220        230        240 
IGEAEARAEA HIKEAIAEEQ RMAARFLNDT DIAKAQRDFE LKKAAYDVEV QTKKAEAEMA 

       250        260        270        280        290        300 
YELQAAKTKQ RIKEEQMQVK VIERTQEIAV QEQEIMRRER ELEATIRRPA EAEKFRMEKL 

       310        320        330        340        350        360 
AEANKQRVVM EAEAEAESIR IRGEAEAFAI AAKAKAEAEQ MAMKAEAYRE YREAAMVEML 

       370        380        390        400        410        420 
LDTLPKVAAE VAAPLSQAKK ITMVSSGTGD IGAAKLTGEV LSIVNKVPEL VKNITGVDIA 


RSVHAG 

O61491 in FASTA format

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