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UniProtKB/Swiss-Prot entry O60732


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAGC1_HUMAN
Primary accession number O60732
Secondary accession numbers O75451 Q8TCV4
Integrated into Swiss-Prot on September 26, 2001
Sequence was last modified on June 27, 2006 (Sequence version 3)
Annotations were last modified on    September 23, 2008 (Entry version 55)
Name and origin of the protein
Protein name Melanoma-associated antigen C1
Synonyms MAGE-C1 antigen
Cancer/testis antigen 7.1
CT7.1
Gene name
Name: MAGEC1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Melanoma;
PubMed=9485030 [NCBI, ExPASy, EBI, Israel, Japan]
Lucas S., De Smet C., Arden K.C., Viars C.S., Lethe B.G., Lurquin C., Boon T.;
"Identification of a new MAGE gene with tumor-specific expression by representational difference analysis.";
Cancer Res. 58:743-752(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Melanoma;
DOI=10.1073/pnas.95.12.6919; PubMed=9618514 [NCBI, ExPASy, EBI, Israel, Japan]
Chen Y.-T., Gure A.O., Tsang S., Stockert E., Jager E., Knuth A., Old L.J.;
"Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library.";
Proc. Natl. Acad. Sci. U.S.A. 95:6919-6923(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03440; PubMed=15772651 [NCBI, ExPASy, EBI, Israel, Japan]
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence of the human X chromosome.";
Nature 434:325-337(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF064589; AAC18837.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF056334; AAC24227.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL022152; CAD27434.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_005453.2; -.
UniGene Hs.132194
3D structure databases
ModBase O60732.
Protein-protein interaction databases
IntAct O60732; -.
Organism-specific databases
H-InvDB HIX0056126; -.
HGNC HGNC:6812; MAGEC1.
GenAtlas MAGEC1.
HPA CAB015452; -.
HPA004622; -.
MIM 300223; gene. [NCBI / EBI]
PharmGKB PA30558; -.
GeneCards O60732.
Gene expression databases
ArrayExpress O60732; -.
CleanEx HS_MAGEC1; -.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR002190; MAGE.
Graphical view of domain structure.
PANTHER PTHR11736; MAGE; 1.
Pfam PF01454; MAGE; 1.
Pfam graphical view of domain structure.
PROSITE PS50838; MAGE; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O60732.
Genome annotation databases
Ensembl ENSG00000155495; Homo sapiens. [Contig view]
GeneID 9947; -.
KEGG hsa:9947; -.
Phylogenomic databases
HOGENOM O60732; -.
HOVERGEN O60732; -.
Other
SOURCE MAGEC1; Homo sapiens.
ProtoNet O60732.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Repeat; Tumor antigen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1142  1142     Melanoma-associated antigen C1. PRO_0000156720
DOMAIN   908   1106  199     MAGE. 
CONFLICT   25     25        C -> Y (in Ref. 1; AAC18837). 
CONFLICT   151    151        T -> I (in Ref. 1 and 2). 
CONFLICT   221    225        TQSTF -> SQRTS (in Ref. 1 and 2). 
CONFLICT   239    239        P -> S (in Ref. 1 and 2). 
CONFLICT   252    253        FS -> SP (in Ref. 1 and 2). 
CONFLICT   264    264        A -> P (in Ref. 1 and 2). 
CONFLICT   267    267        S -> P (in Ref. 1 and 2). 
CONFLICT   274    274        P -> R (in Ref. 1 and 2). 
CONFLICT   281    283        VSL -> LSI (in Ref. 1 and 2). 
CONFLICT   299    299        P -> A (in Ref. 1 and 2). 
CONFLICT   309    311        SSS -> PSF (in Ref. 2; AAC24227). 
CONFLICT   316    318        LSL -> VSI (in Ref. 2; AAC24227). 
CONFLICT   327    327        H -> Q (in Ref. 1 and 2). 
CONFLICT   337    337        L -> P (in Ref. 2; AAC24227). 
CONFLICT   342    343        MT -> VS (in Ref. 2; AAC24227). 
CONFLICT   353    353        I -> L (in Ref. 2; AAC24227). 
CONFLICT   360    361        SA -> RT (in Ref. 2; AAC24227). 
CONFLICT   467    467        H -> Q (in Ref. 1; AAC18837). 
Sequence information
Length: 1142 AA [This is the length of the unprocessed precursor] Molecular weight: 123643 Da [This is the MW of the unprocessed precursor] CRC64: 6C9AE820156F3C50 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGDKDMPTAG MPSLLQSSSE SPQSCPEGED SQSPLQIPQS SPESDDTLYP LQSPQSRSEG 

        70         80         90        100        110        120 
EDSSDPLQRP PEGKDSQSPL QIPQSSPEGD DTQSPLQNSQ SSPEGKDSLS PLEISQSPPE 

       130        140        150        160        170        180 
GEDVQSPLQN PASSFFSSAL LSIFQSSPES TQSPFEGFPQ SVLQIPVSAA SSSTLVSIFQ 

       190        200        210        220        230        240 
SSPESTQSPF EGFPQSPLQI PVSRSFSSTL LSIFQSSPER TQSTFEGFAQ SPLQIPVSPS 

       250        260        270        280        290        300 
SSSTLLSLFQ SFSERTQSTF EGFAQSSLQI PVSPSFSSTL VSLFQSSPER TQSTFEGFPQ 

       310        320        330        340        350        360 
SPLQIPVSSS SSSTLLSLFQ SSPERTHSTF EGFPQSLLQI PMTSSFSSTL LSIFQSSPES 

       370        380        390        400        410        420 
AQSTFEGFPQ SPLQIPGSPS FSSTLLSLFQ SSPERTHSTF EGFPQSPLQI PMTSSFSSTL 

       430        440        450        460        470        480 
LSILQSSPES AQSAFEGFPQ SPLQIPVSSS FSYTLLSLFQ SSPERTHSTF EGFPQSPLQI 

       490        500        510        520        530        540 
PVSSSSSSST LLSLFQSSPE CTQSTFEGFP QSPLQIPQSP PEGENTHSPL QIVPSLPEWE 

       550        560        570        580        590        600 
DSLSPHYFPQ SPPQGEDSLS PHYFPQSPPQ GEDSLSPHYF PQSPQGEDSL SPHYFPQSPP 

       610        620        630        640        650        660 
QGEDSMSPLY FPQSPLQGEE FQSSLQSPVS ICSSSTPSSL PQSFPESSQS PPEGPVQSPL 

       670        680        690        700        710        720 
HSPQSPPEGM HSQSPLQSPE SAPEGEDSLS PLQIPQSPLE GEDSLSSLHF PQSPPEWEDS 

       730        740        750        760        770        780 
LSPLHFPQFP PQGEDFQSSL QSPVSICSSS TSLSLPQSFP ESPQSPPEGP AQSPLQRPVS 

       790        800        810        820        830        840 
SFFSYTLASL LQSSHESPQS PPEGPAQSPL QSPVSSFPSS TSSSLSQSSP VSSFPSSTSS 

       850        860        870        880        890        900 
SLSKSSPESP LQSPVISFSS STSLSPFSEE SSSPVDEYTS SSDTLLESDS LTDSESLIES 

       910        920        930        940        950        960 
EPLFTYTLDE KVDELARFLL LKYQVKQPIT KAEMLTNVIS RYTGYFPVIF RKAREFIEIL 

       970        980        990       1000       1010       1020 
FGISLREVDP DDSYVFVNTL DLTSEGCLSD EQGMSQNRLL ILILSIIFIK GTYASEEVIW 

      1030       1040       1050       1060       1070       1080 
DVLSGIGVRA GREHFAFGEP RELLTKVWVQ EHYLEYREVP NSSPPRYEFL WGPRAHSEVI 

      1090       1100       1110       1120       1130       1140 
KRKVVEFLAM LKNTVPITFP SSYKDALKDV EERAQAIIDT TDDSTATESA SSSVMSPSFS 


SE 

O60732 in FASTA format

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