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UniProtKB/Swiss-Prot entry O60163


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AK_SCHPO
Primary accession number O60163
Secondary accession numbers None
Integrated into Swiss-Prot on September 26, 2001
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 53)
Name and origin of the protein
Protein name Probable aspartokinase
Synonyms EC 2.7.2.4
Aspartate kinase
Gene name
ORFNames: SPBC19F5.04
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326 AND THR-328, AND MASS SPECTROMETRY.
DOI=10.1021/pr7006335; PubMed=18257517 [NCBI, ExPASy, EBI, Israel, Japan]
Wilson-Grady J.T., Villen J., Gygi S.P.;
"Phosphoproteome analysis of fission yeast.";
J. Proteome Res. 7:1088-1097(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329671; CAA18652.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T39822; T39822.
RefSeq NP_596542.1; -.
3D structure databases
ModBase O60163.
Enzyme and pathway databases
BioCyc SPOM-XXX-01:SPOM-XXX-01-004539-MON; -.
Organism-specific databases
GeneDB_Spombe SPBC19F5.04; -.
Gene expression databases
ArrayExpress O60163; -.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from GeneDB_SPombe).
GO:0016597; Molecular function: amino acid binding (inferred from electronic annotation from InterPro).
GO:0004072; Molecular function: aspartate kinase activity (inferred from electronic annotation from InterPro).
GO:0009088; Biological process: threonine biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002912; ACT_bd.
IPR001048; Asp/Glu/Uridylate_kinase.
IPR001341; Asp_kin_reg.
Graphical view of domain structure.
Gene3D G3DSA:3.40.1160.10; Aa_kinase; 1.
Pfam PF00696; AA_kinase; 1.
PF01842; ACT; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00657; asp_kinases; 1.
PROSITE PS00324; ASPARTOKINASE; 1.
Genome annotation databases
GeneID 2540602; -.
KEGG spo:SPBC19F5.04; -.
NMPDR fig|4896.1.peg.2408; -.
Other
ProtoNet O60163.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Kinase; Phosphoprotein; Repeat; Threonine biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   519  519     Probable aspartokinase. PRO_0000066689
DOMAIN   359   431  73     ACT 1. 
DOMAIN   435   503  69     ACT 2. 
MOD_RES   326   326        Phosphoserine. 
MOD_RES   328   328        Phosphothreonine. 
Sequence information
Length: 519 AA [This is the length of the unprocessed precursor] Molecular weight: 56813 Da [This is the MW of the unprocessed precursor] CRC64: 0B392EB4AE8ECFCB [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSIAKNIEND PSKGWVVQKF GGTSVGKFPI KIAVDVAKEY LSTKRVALVC SARSTDTKAE 

        70         80         90        100        110        120 
GTTTRLIRAT EAALRPAVGS VHDLVRIIET DHVQAARDFI QDVGIQDELI DAFHADCVEL 

       130        140        150        160        170        180 
EQYLNAIRVL SEVSPRTRDL VIGMGERLSC RFMAAVLKDQ GIDSEFIDMS HIIDEQREWR 

       190        200        210        220        230        240 
NLDASFYAYL ASQLASKVTA VGNKVPVVTG FFGMVPGGLL SQIGRGYTDF CAALLAVGLN 

       250        260        270        280        290        300 
ADELQIWKEV DGIFTADPRK VPTARLLPLI TPEEAAELTY YGSEVIHPFT MSQVVHARIP 

       310        320        330        340        350        360 
IRIKNVGNPR GKGTVIFPDT ISRHGSATPP HPPKIMPDDI SASLANKGAT AVTIKDTIMV 

       370        380        390        400        410        420 
INIQSNRKIS AHGFLASIFA ILDKYKLAVD LITTSEVHVS MALYEESDDG NMHEAFVELR 

       430        440        450        460        470        480 
RLGTLDILHG LAILSLVGKH MRNTTGYAGR MFCKLAEAQI NIEMISQGAS EINISCVIDE 

       490        500        510 
KMAVKALNVI HKELLEPLAL HEVPSQASML VEKPWLYSA 

O60163 in FASTA format

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