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UniProtKB/Swiss-Prot entry O59808


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name BADH_SCHPO
Primary accession number O59808
Secondary accession numbers None
Integrated into Swiss-Prot on July 11, 2002
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 58)
Name and origin of the protein
Protein name Probable betaine aldehyde dehydrogenase
Synonyms BADH
EC 1.2.1.8
Meiotic expression up-regulated protein 8
Gene name
Name: meu8
ORFNames: SPCC550.10
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 420-500.
STRAIN=CD16-1;
DOI=10.1093/nar/29.11.2327; PubMed=11376151 [NCBI, ExPASy, EBI, Israel, Japan]
Watanabe T., Miyashita K., Saito T.T., Yoneki T., Kakihara Y., Nabeshima K., Kishi Y.A., Shimoda C., Nojima H.;
"Comprehensive isolation of meiosis-specific genes identifies novel proteins and unusual non-coding transcripts in Schizosaccharomyces pombe.";
Nucleic Acids Res. 29:2327-2337(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329672; CAA19114.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB054529; BAB60885.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T41385; T41385.
RefSeq NP_588102.1; -.
3D structure databases
HSSP P51977; 1BXS. [HSSP ENTRY / PDB]
ModBase O59808.
Enzyme and pathway databases
BioCyc SPOM-XXX-01:SPOM-XXX-01-000048-MON; -.
Organism-specific databases
GeneDB_Spombe SPCC550.10; -.
Gene expression databases
ArrayExpress O59808; -.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from GeneDB_SPombe).
GO:0005634; Cellular component: nucleus (inferred from direct assay from GeneDB_SPombe).
GO:0008802; Molecular function: betaine-aldehyde dehydrogenase activity (inferred from electronic annotation from EC).
GO:0033554; Biological process: cellular response to stress (inferred from expression pattern from GeneDB_SPombe).
GO:0007126; Biological process: meiosis (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
Genome annotation databases
GeneID 2539264; -.
KEGG spo:SPCC550.10; -.
NMPDR fig|4896.1.peg.440; -.
Other
ProtoNet O59808.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Meiosis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   500  500     Probable betaine aldehyde dehydrogenase. PRO_0000056531
NP_BIND   249   254  6     NAD (By similarity). 
ACT_SITE   271   271        Proton acceptor (By similarity). 
ACT_SITE   305   305        Nucleophile (By similarity). 
SITE   173   173  1     Transition state stabilizer (By similarity). 
Sequence information
Length: 500 AA [This is the length of the unprocessed precursor] Molecular weight: 54144 Da [This is the MW of the unprocessed precursor] CRC64: BFFF9D7C1A11ACA0 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTIDLNVIQS DIISARRAPE NSLFIDGKFV SPIEPAAKPI PLINPATEEI IGTCANASAK 

        70         80         90        100        110        120 
DVDSAVENAY NTFRSGIWAK WPGKQRGLVL RKIAKMMREK RELLAGIDTI NCGKPTPYAL 

       130        140        150        160        170        180 
FDIDSCADMF EYYAEVAETD NPTVKVPLPN NPGFCAFEKR FPRGVIGVIT PWNFPLKMAL 

       190        200        210        220        230        240 
WKLVPAIASG NCVVLKPSEL APWSCLEFAL ICKEAGLPDG VLNVIIGSGK ESGAALSCHP 

       250        260        270        280        290        300 
KIAYLAFTGS LATGKKIMHA AAENIVPLTL ELGGKSPLII CEDADLSLAI PSAAFAIFFN 

       310        320        330        340        350        360 
QGEACTAASR LIVHESVADE VLGGLVSEAN KLIIGNGLDP QVTLGPVVSK TQFEKIVSYI 

       370        380        390        400        410        420 
QSAINEGCKC VVGGLPRSEQ KGYFIPPTVF TNVQTHNKIW REEIFGPVLA VKTFHTNEEA 

       430        440        450        460        470        480 
LELANDSEYG LGSGVFSTNP KTLEFFSNNI EAGMCSLNNY HVVTHELPWI GWKHSGLGVG 

       490        500 
LSKHGYNEYM RLKQITQYVG 

O59808 in FASTA format

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