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UniProtKB/Swiss-Prot entry O58413


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name VORA_PYRHO
Primary accession number O58413
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on May 30, 2000 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 45)
Name and origin of the protein
Protein name Ketoisovalerate oxidoreductase subunit vorA
Synonyms VOR
EC 1.2.7.7
2-oxoisovalerate oxidoreductase alpha chain
2-oxoisovalerate ferredoxin reductase subunit alpha
Gene name
Name: vorA
OrderedLocusNames: PH0680
From
Pyrococcus horikoshii [TaxID: 53953] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=OT3;
DOI=10.1093/dnares/5.2.55; PubMed=9679194 [NCBI, ExPASy, EBI, Israel, Japan]
Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
DNA Res. 5:55-76(1998).
Comments
  • CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
  • SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one gamma chain (By similarity).
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000001; BAA29771.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A71114; A71114.
RefSeq NP_142630.1; -.
3D structure databases
ModBase O58413.
Ontologies
GO
GO:0043807; Molecular function: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity (inferred from electronic annotation from EC).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
IPR015941; Transketolase_C-like.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.920; Transketo_C_like; 1.
Pfam PF01855; POR_N; 1.
Pfam graphical view of domain structure.
Genome annotation databases
GeneID 1443008; -.
GenomeReviews BA000001_GR; PH0680.
KEGG pho:PH0680; -.
NMPDR fig|70601.1.peg.661; -.
Phylogenomic databases
HOGENOM O58413; -.
Genome annotation databases
CMR O58413; PH0680.
Other
ProtoNet O58413.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   394  394     Ketoisovalerate oxidoreductase subunit vorA. PRO_0000099953
Sequence information
Length: 394 AA [This is the length of the unprocessed precursor] Molecular weight: 44126 Da [This is the MW of the unprocessed precursor] CRC64: 68E5038B32D63FD3 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEYNPIKKVV SGNYAAAYAA LHARVQVVAA YPITPQTSII EKIAEFIANG EADIQYIPVE 

        70         80         90        100        110        120 
SEHSAMAACI GASATGARVF TATSAQGLAL MHEMLHWAAG SRLPIVMVNV NRAMAPPWSV 

       130        140        150        160        170        180 
WDDQTDSLSQ RDTGWMQFYA ENNQEVYDGV LMAYKVAETV NIPTMIIESA FILSHTYEVV 

       190        200        210        220        230        240 
NMIPQELVDE FLPPRKPLYT LTDFENPIAV GALATPADYY EFRYKIAKAH EEAKKVIKSV 

       250        260        270        280        290        300 
GKEFGERFGR DYSKMIETGY IEDADFVFMG MGSLMGTVKE AVDLLRKEGY KVGYAKVRWF 

       310        320        330        340        350        360 
RPFPKEELLE IAESVKGIAV LDRNFSFGQE GILFTEAKGA LYNTGVRPIM KDYIVGLGGR 

       370        380        390 
DFTVRDVKAI AEDMKKVVES GKLDKEIEWY HLKR 

O58413 in FASTA format

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