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UniProtKB/Swiss-Prot entry O57380

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH8_RANPE
Primary accession number O57380
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 60)
Name and origin of the protein
Protein name NADP-dependent alcohol dehydrogenase
Synonym EC 1.1.1.2
Gene name
Name: ADH8
From
Rana perezi (Perez's frog) (Western Mediterranian green frog) [TaxID: 8403] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Pelophylax.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-373.
TISSUE=Stomach;
DOI=10.1074/jbc.274.37.26021; PubMed=10473548 [NCBI, ExPASy, EBI, Israel, Japan]
Peralba J.M., Cederlund E., Crosas B., Moreno A., Julia P., Martinez S.E., Persson B., Farres J., Pares X., Joernvall H.;
"Structural and enzymatic properties of a gastric NADP(H)-dependent and retinal-active alcohol dehydrogenase.";
J. Biol. Chem. 274:26021-26026(1999).
[2]
 X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
DOI=10.1107/S090744490201661X; PubMed=12554944 [NCBI, ExPASy, EBI, Israel, Japan]
Valencia E., Rosell A., Larroy C., Farres J., Biosca J.A., Fita I., Pares X., Ochoa W.F.;
"Crystallization and preliminary X-ray analysis of NADP(H)-dependent alcohol dehydrogenases from Saccharomyces cerevisiae and Rana perezi.";
Acta Crystallogr. D 59:334-337(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ002554; CAA05553.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
PDB
1P0C; X-ray; 2.20 A; A/B=1-373.[ExPASy / RCSB / EBI]
1P0F; X-ray; 1.80 A; A/B=1-373.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1P0C; -.
1P0F; -.
ModBase O57380.
Ontologies
GO
GO:0008106; Molecular function: alcohol dehydrogenase (NADP+) activity (inferred from electronic annotation from EC).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
Phylogenomic databases
HOVERGEN O57380; -.
Other
ProtoNet O57380.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Acetylation; Direct protein sequencing; Metal-binding; NADP; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   373  372     NADP-dependent alcohol dehydrogenase. PRO_0000160756
METAL   47    47        Zinc 1; catalytic (By similarity). 
METAL   68    68        Zinc 1; catalytic (By similarity). 
METAL   98    98        Zinc 2 (By similarity). 
METAL   101   101        Zinc 2 (By similarity). 
METAL   104   104        Zinc 2 (By similarity). 
METAL   112   112        Zinc 2 (By similarity). 
METAL   174   174        Zinc 1; catalytic (By similarity). 
MOD_RES   2     2        N-acetylcysteine (By similarity). 
CONFLICT   74    74        V -> L (in Ref. 1; AA sequence). 
CONFLICT   134   134        R -> K (in Ref. 1; AA sequence). 
CONFLICT   142   142        V -> M (in Ref. 1; AA sequence). 
STRAND   8    17  10      
STRAND   23    29  7      
STRAND   36    45  10      
HELIX   48    54  7      
STRAND   62    65  4      
STRAND   70    77  8      
STRAND   89    92  4      
STRAND   99   101  3      
HELIX   102   105  4      
TURN   117   119  3      
STRAND   130   133  4      
STRAND   136   139  4      
TURN   142   144  3      
STRAND   147   154  8      
STRAND   157   161  5      
HELIX   167   173  7      
HELIX   175   184  10      
TURN   185   187  3      
STRAND   194   198  5      
HELIX   202   213  12      
STRAND   217   222  6      
HELIX   226   228  3      
HELIX   229   235  7      
STRAND   238   241  4      
HELIX   243   245  3      
HELIX   250   257  8      
STRAND   262   267  6      
HELIX   272   280  9      
TURN   284   286  3      
STRAND   288   291  4      
STRAND   301   303  3      
HELIX   306   309  4      
STRAND   313   316  4      
HELIX   319   321  3      
HELIX   324   326  3      
HELIX   327   335  9      
HELIX   341   344  4      
STRAND   345   349  5      
HELIX   351   353  3      
HELIX   354   362  9      
STRAND   366   372  7      
Sequence information
Length: 373 AA [This is the length of the unprocessed precursor] Molecular weight: 39168 Da [This is the MW of the unprocessed precursor] CRC64: 954A502267E8DE49 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MCTAGKDITC KAAVAWEPHK PLSLETITVA PPKAHEVRIK ILASGICGSD SSVLKEIIPS 

        70         80         90        100        110        120 
KFPVILGHEA VGVVESIGAG VTCVKPGDKV IPLFVPQCGS CRACKSSNSN FCEKNDMGAK 

       130        140        150        160        170        180 
TGLMADMTSR FTCRGKPIYN LVGTSTFTEY TVVADIAVAK IDPKAPLESC LIGCGFATGY 

       190        200        210        220        230        240 
GAAVNTAKVT PGSTCAVFGL GGVGFSAIVG CKAAGASRII GVGTHKDKFP KAIELGATEC 

       250        260        270        280        290        300 
LNPKDYDKPI YEVICEKTNG GVDYAVECAG RIETMMNALQ STYCGSGVTV VLGLASPNER 

       310        320        330        340        350        360 
LPLDPLLLLT GRSLKGSVFG GFKGEEVSRL VDDYMKKKIN VNFLVSTKLT LDQINKAFEL 

       370 
LSSGQGVRSI MIY
O57380 in FASTA format

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