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UniProtKB/Swiss-Prot entry O52594

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information

Entry name

ACKA_CLOTH

Primary accession number

O52594

Secondary accession number

A3DE81

Integrated into Swiss-Prot on

May 30, 2000

Sequence was last modified on

June 1, 1998 (Sequence version 1)

Annotations were last modified on

November 25, 2008 (Entry version 49)

Name and origin of the protein

Protein name

Acetate kinase

Synonyms

EC 2.7.2.1
Acetokinase

Gene name

	Name:	ackA
	Synonyms:	ack
	OrderedLocusNames:	Cthe_1028

From

Clostridium thermocellum (strain ATCC 27405 / DSM 1237)

[TaxID: 203119]

[HAMAP proteome]

Taxonomy

Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.

Protein existence

3: Inferred from homology;

References

[1]

NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Stevens D.R., Guerinot M.L., Lynd L.R.;
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Wu J.H.D., Newcomb M., Richardson P.;
"Complete sequence of Clostridium thermocellum ATCC 27405.";
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Involved in the activation of acetate to acetyl CoA and the secretion of acetate (By similarity).
CATALYTIC ACTIVITY: ATP + acetate = ADP + acetyl phosphate.
CATALYTIC ACTIVITY: ATP + propanoate = ADP + propanoyl phosphate.
PATHWAY: Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the acetokinase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF041841; AAB96952.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
CP000568; ABN52260.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001037453.1; -.

3D structure databases

HSSP

P38502; 1G99. [HSSP ENTRY / PDB]

ModBase

O52594.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0008776;	Molecular function: acetate kinase activity (inferred from electronic annotation from HAMAP).
GO:0006082;	Biological process: organic acid metabolic process (inferred from electronic annotation from InterPro).
GO:0016310;	Biological process: phosphorylation (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00020; -; 1.
PBIL [Tree]

InterPro

IPR000890; Acetate_kin.
IPR004372; AckA.
Graphical view of domain structure.

PANTHER

PTHR21060; Acetate_kin; 1.
PTHR21060:SF11; AckA; 1.

Pfam

PF00871; Acetate_kinase; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000722; Acetate_prop_kin; 1.

PRINTS

PR00471; ACETATEKNASE.

TIGRFAMs

TIGR00016; ackA; 1.

PROSITE

PS01075; ACETATE_KINASE_1; 1.
PS01076; ACETATE_KINASE_2; 1.

Genome annotation databases

GeneID

4811322; -.

GenomeReviews

CP000568_GR; Cthe_1028.

KEGG

cth:Cthe_1028; -.

NMPDR

fig|203119.1.peg.567; -.

CMR

O52594; Cthe_1028.

Other

ProtoNet

O52594.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; Kinase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 399`	`399`		`Acetate kinase.`	`PRO_0000107549`

Sequence information

Length: 399 AA [This is the length of the unprocessed precursor]

Molecular weight: 43966 Da [This is the MW of the unprocessed precursor]

CRC64: 1DEF07FA0A72226B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNILVINTGS SSLKYQLIDM TNESVLAKGV CDRIGLEHSF LKHTKTGGET VVIEKDLYNH 

        70         80         90        100        110        120 
KLAIQEVISA LTDEKIGVIK SMSEISAVGH RIVHGGEKFK ESAIIDEDVM KAIRDCVELA 

       130        140        150        160        170        180 
PLHNPSNIIG IEACKQILPD VPMVAVFDTA FHQTMPRHAY IYALPYEIYE KYKLRKYGFH 

       190        200        210        220        230        240 
GTSHKYVAHR AAQMLGKPIE SLKLITCHLG NGASICAVKG GKSVDTSMGF TPLQGLCMGT 

       250        260        270        280        290        300 
RSGNVDPAVI TYLMEKEKMN INDINNFLNK KSGVLGISGV SSDFRDVQDA AEKGDDRAQL 

       310        320        330        340        350        360 
ALDIFCYGVR KYIGKYIAVL NGVDAVVFTA GIGENNAYIR REVLKDMDFF GIKIDLDKNE 

       370        380        390 
VKGKEADISA PDAKVKTLVI PTNEELEIAR ETLRLVKNL

O52594 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools