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UniProtKB/Swiss-Prot entry O51628

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH_BORBU
Primary accession number O51628
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on June 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 64)
Name and origin of the protein
Protein name Probable 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Synonyms HMG-CoA reductase
EC 1.1.1.88
Gene name
OrderedLocusNames: BB_0685
From
Borrelia burgdorferi (Lyme disease spirochete) [TaxID: 139] [HAMAP proteome]
Taxonomy Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Borrelia; Borrelia burgdorferi group.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35210 / B31 / CIP 102532 / DSM 4680;
DOI=10.1038/37551; PubMed=9403685 [NCBI, ExPASy, EBI, Israel, Japan]
Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C.;
"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
Nature 390:580-586(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000783; AAC67032.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D70185; D70185.
RefSeq NP_212819.1; -.
3D structure databases
HSSP P13702; 1QAY. [HSSP ENTRY / PDB]
ModBase O51628.
Enzyme and pathway databases
BioCyc BBUR224326:BB_0685-MON; -.
Ontologies
GO
GO:0050662; Molecular function: coenzyme binding (inferred from electronic annotation from InterPro).
GO:0004420; Molecular function: hydroxymethylglutaryl-CoA reductase (NADPH) activity (inferred from electronic annotation from InterPro).
GO:0042282; Molecular function: hydroxymethylglutaryl-CoA reductase activity (inferred from electronic annotation from EC).
GO:0015936; Biological process: coenzyme A metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004553; HMG_CoA_Rdtase_II_bac/I_arc.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00532; HMG_CoA_R_NAD; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; FALSE_NEG.
PS00318; HMG_COA_REDUCTASE_2; FALSE_NEG.
PS01192; HMG_COA_REDUCTASE_3; FALSE_NEG.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 1195537; -.
GenomeReviews AE000783_GR; BB_0685.
KEGG bbu:BB0685; -.
NMPDR fig|224326.1.peg.1069; -.
TIGR BB_0685; -.
Phylogenomic databases
HOGENOM O51628; -.
Other
ProtoNet O51628.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   431  431     Probable 3-hydroxy-3-methylglutaryl-coenzyme A reductase. PRO_0000114466
ACT_SITE   85    85        Charge relay system (By similarity). 
ACT_SITE   278   278        Charge relay system (By similarity). 
ACT_SITE   375   375        Proton donor (By similarity). 
Sequence information
Length: 431 AA [This is the length of the unprocessed precursor] Molecular weight: 48922 Da [This is the MW of the unprocessed precursor] CRC64: A98DA9099AB0CDB4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNLESLSSFM ELSKNFRHKS VLEKRQEIKS FLELSYKDFF YNNANEDFLF NMIENYIGYL 

        70         80         90        100        110        120 
SFPIGIVKNL KINGKYYSLP IATEESSVVA ALNFAAKILE NADLRYSLGE VLGISQIYIK 

       130        140        150        160        170        180 
SEKDLSKIFV DLGDKIKTWI EPLLTNMNQR GGGFRRLSTR HIKELGIQKL NIYVDTCDAM 

       190        200        210        220        230        240 
GANLLNSIAE RVAEFIFLEF GYECVLKVLS NDISEFTAKA RFVLDFKHLL PGKEDSWNLA 

       250        260        270        280        290        300 
KKIELISSIG FYEEERAVTN NKGIMNGITG VCLATFNDTR ALEASVHKFA SKSGKYFPLS 

       310        320        330        340        350        360 
KFYTTDNALV GEIEIPLQVG TKGGVISFNE ASILSFKIMN VNSKSEFIGI LSCVGLASNF 

       370        380        390        400        410        420 
AALRALAFNG IQKGHMRLHV NKILHLLKTK YNISDFEKDK LLLEMERMNI YSFDFAFKIL 

       430 
KKIRLENENK V
O51628 in FASTA format

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