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UniProtKB/Swiss-Prot entry O45687

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH2_CAEEL
Primary accession number O45687
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on June 1, 1998 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 55)
Name and origin of the protein
Protein name Alcohol dehydrogenase 2
Synonyms EC 1.1.1.1
Sorbitol dehydrogenase family protein 2
Gene name
Name: sodh-2
ORFNames: K12G11.4
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z81570; CAB04603.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T23625; T23625.
RefSeq NP_505992.1; -.
UniGene Cel.2991
3D structure databases
ModBase O45687.
Organism-specific databases
WormBase WBGene00010791; sodh-2.
WormPep K12G11.4; CE12214. [WormPep / WorfDB]
Gene expression databases
ArrayExpress O45687; -.
Ontologies
GO
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0008340; Biological process: determination of adult life span (inferred from mutant phenotype from WormBase).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
Genome annotation databases
Ensembl K12G11.4; Caenorhabditis elegans. [Contig view]
GeneID 179628; -.
KEGG cel:K12G11.4; -.
NMPDR fig|6239.3.peg.19849; -.
Other
NextBio 906206; -.
ProtoNet O45687.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   351  351     Alcohol dehydrogenase 2. PRO_0000160694
NP_BIND   181   187  7     NAD (By similarity). 
NP_BIND   271   273  3     NAD (By similarity). 
METAL   47    47        Zinc 1; catalytic (By similarity). 
METAL   70    70        Zinc 1; catalytic (By similarity). 
METAL   101   101        Zinc 2 (By similarity). 
METAL   104   104        Zinc 2 (By similarity). 
METAL   107   107        Zinc 2 (By similarity). 
METAL   115   115        Zinc 2 (By similarity). 
METAL   157   157        Zinc 1; catalytic (By similarity). 
BINDING   205   205        NAD (By similarity). 
BINDING   209   209        NAD (By similarity). 
BINDING   343   343        NAD (By similarity). 
Sequence information
Length: 351 AA [This is the length of the unprocessed precursor] Molecular weight: 37945 Da [This is the MW of the unprocessed precursor] CRC64: D806D1DA6AB9AEEB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSSANIPATQ SALIFEKYGG PLEVRQVSVP QPQENELLVK IEYSGICHSD LHTWEGDFEY 

        70         80         90        100        110        120 
ASICPLIGGH EGAGTVVTIG SKVKGWNIGD RAGIKLINAN CLNCEYCKTG HEPLCDHIQN 

       130        140        150        160        170        180 
YGIDRHGTFQ EYLTIRDIDA IKVSNDTNLA AAAPVLCGGV TAYKSLKATN VKPGQIVVLT 

       190        200        210        220        230        240 
GAGGGLGSFG IQYAKAMGMR VVAVDHISKE DHCRNLGAEW FVDAFDTPDI VAHIRKLTNG 

       250        260        270        280        290        300 
GAHGVVSFAA AKKPMEYALE YVRKRGTVVF VGLPKDGTIP LDTLSLICNE ITVKGSIVGS 

       310        320        330        340        350 
RMDVDEAIDF ITRGIVHVPI ELVKLEDVPS VYQRMKDGKV TSRVVVDFSM R
O45687 in FASTA format

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