[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1023/A:1017035109224; PubMed=9720289 [NCBI, ExPASy, EBI, Israel, Japan] Zeng L.-W., Comeron J.M., Chen B., Kreitman M.; "The molecular clock revisited: the rate of synonymous vs. replacement change in Drosophila."; Genetica 102:369-382(1998).

Comments

FUNCTION: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which spontaneously decomposes to form allantoin.
CATALYTIC ACTIVITY: Urate + O₂ + H₂O = 5-hydroxyisourate + H₂O₂.
PATHWAY: Purine metabolism; uric acid degradation; (S)-allantoin from uric acid: step 1/3 .
SUBCELLULAR LOCATION: Peroxisome.
DEVELOPMENTAL STAGE: Third instar larvae and adult.
SIMILARITY: Belongs to the uricase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF025816; AAB87901.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

Q00511; 1UOX. [HSSP ENTRY / PDB]

ModBase

O44111.

Organism-specific databases

FlyBase

FBgn0021077; Dsub\Uro.

Ontologies

GO:0005777;	Cellular component: peroxisome (inferred from electronic annotation from UniProtKB-KW).
GO:0004846;	Molecular function: urate oxidase activity (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006144;	Biological process: purine base metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR002042; Uricase.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.270.10; Uricase; 1.

PANTHER

PTHR10395:SF1; Uricase; 1.

Pfam

PF01014; Uricase; 2.
Pfam graphical view of domain structure.

PRINTS

PR00093; URICASE.

ProDom

PD003367; Uricase; 2.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR03383; urate_oxi; 1.

PROSITE

PS00366; URICASE; 1.

Other

ProtoNet

O44111.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Oxidoreductase; Peroxisome; Purine metabolism.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 339`	`>339`	`Uricase.`	`PRO_0000165993`
`MOTIF`	`337 339`	`3`	`Microbody targeting signal (Potential).`
`ACT_SITE`	`218 218`		`Charge relay system (By similarity).`
`ACT_SITE`	`267 267`		`Charge relay system (By similarity).`
`NON_TER`	`1 1`

Sequence information

Length: 339 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 38437 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 34439F6B6078DC6E [This is a checksum on the sequence]

        10         20         30         40         50         60 
LRQPSSASNR TAASLDGQET PFQYEITDHG YGKDAVKVLH VSRKGPVHTI QEFEVGTHLK 

        70         80         90        100        110        120 
LYSKKDYYQG NNSDIVATDS QKNTVYLLAK KYGIESPEKF ALLLGQHFLN KYSHVEEAHV 

       130        140        150        160        170        180 
HVETYPWQRV CQEETKASTT VGQGSCNFSS IDNRSLHNHA FIFTPTALHY CDVVIXRQDP 

       190        200        210        220        230        240 
KQTVITGIKG LRVLKTTQSS FVNFVNDEXR SLPDQYDRIF STVVDCSWEY SDTDTVNFSR 

       250        260        270        280        290        300 
AWQQVKNIIL RNFAGDPQVG VSSPSVQHTL YLSEKQVLDV IPQVSVISMT MPNKHYFNFD 

       310        320        330 
TKPFQQIVPG DNNEVFIPVD KPHGTIYAQL ARKNLNSHL

O44111 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools