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UniProtKB/Swiss-Prot entry O44104

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G3P2_DROPS
Primary accession number O44104
Secondary accession number Q29CT3
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on May 30, 2006 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 54)
Name and origin of the protein
Protein name Glyceraldehyde-3-phosphate dehydrogenase 2
Synonyms EC 1.2.1.12
Glyceraldehyde-3-phosphate dehydrogenase II
GAPDH II
Gene name
Name: Gapdh2
ORFNames: GA21397
From
Drosophila pseudoobscura pseudoobscura (Fruit fly) [TaxID: 46245] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MV2-25;
DOI=10.1101/gr.3059305; PubMed=15632085 [NCBI, ExPASy, EBI, Israel, Japan]
Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.;
"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution.";
Genome Res. 15:1-18(2005).
[2]
 NUCLEOTIDE SEQUENCE [MRNA] OF 11-314.
DOI=10.1023/A:1017035109224; PubMed=9720289 [NCBI, ExPASy, EBI, Israel, Japan]
Zeng L.-W., Comeron J.M., Chen B., Kreitman M.;
"The molecular clock revisited: the rate of synonymous vs. replacement change in Drosophila.";
Genetica 102:369-382(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CH475410; EAL29271.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF025809; AAB87894.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_001352353.1; -.
3D structure databases
HSSP P56649; 1DSS. [HSSP ENTRY / PDB]
SMR O44104; 2-332.
ModBase O44104.
Organism-specific databases
FlyBase FBgn0012698; Dpse\Gapdh2.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004365; Molecular function: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity (inferred from electronic annotation from InterPro).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000173; GlycerAld_3-P_DHase.
IPR006424; Glyceraldehyde-3-P_DHase_1.
Graphical view of domain structure.
PANTHER PTHR10836; GAP_DH; 1.
Pfam PF02800; Gp_dh_C; 1.
PF00044; Gp_dh_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000149; GAP_DH; 1.
PRINTS PR00078; G3PDHDRGNASE.
TIGRFAMs TIGR01534; GAPDH-I; 1.
PROSITE PS00071; GAPDH; 1.
Genome annotation databases
GeneID 4811785; -.
KEGG dpo:Dpse_GA21397; -.
Other
ProtoNet O44104.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   332  332     Glyceraldehyde-3-phosphate dehydrogenase 2. PRO_0000145524
NP_BIND   11    12  2     NAD (By similarity). 
REGION   148   150  3     Glyceraldehyde 3-phosphate binding (By similarity). 
REGION   208   209  2     Glyceraldehyde 3-phosphate binding (By similarity). 
ACT_SITE   149   149        Nucleophile (By similarity). 
BINDING   32    32        NAD (By similarity). 
BINDING   77    77        NAD; via carbonyl oxygen (By similarity). 
BINDING   179   179        Glyceraldehyde 3-phosphate (By similarity). 
BINDING   231   231        Glyceraldehyde 3-phosphate (By similarity). 
BINDING   313   313        NAD (By similarity). 
SITE   176   176  1     Activates thiol group during catalysis (By similarity). 
Sequence information
Length: 332 AA [This is the length of the unprocessed precursor] Molecular weight: 35312 Da [This is the MW of the unprocessed precursor] CRC64: 9E58BEB163B59983 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSKIGINGFG RIGRLVLRAA IDKGASVVAV NDPFIDVNYM VYLFKFDSTH GRFKGTVAAE 

        70         80         90        100        110        120 
GGFLVVNGQK ITVFSERDPA NINWASAGAE YVVESTGVFT TIEKASTHLK GGAKKVVISA 

       130        140        150        160        170        180 
PSADAPMFVC GVNLDAYKPD MKVVSNASCT TNCLAPLAKV INDNFEIVEG LMTTVHATTA 

       190        200        210        220        230        240 
TQKTVDGPSG KLWRDGRGAA QNIIPAATGA AKAVGKVIPA LNGKLTGMAF RVPTPNVSVV 

       250        260        270        280        290        300 
DLTVRLGKGA SYDEIKAKVQ EAANGPLKGI LGYTDEEVVS TDFLSDTHSS VFDAKAGISL 

       310        320        330 
NDKFVKLISW YDNEFGYSNR VIDLIKYMQS KD
O44104 in FASTA format

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