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UniProtKB/Swiss-Prot entry O42145

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name C19AA_DANRE
Primary accession number O42145
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 58)
Name and origin of the protein
Protein name Cytochrome P450 19A1a
Synonyms EC 1.14.14.1
CYPXIX
Aromatase
Estrogen synthetase
P-450AROM
Gene name
Name: cyp19a1a
Synonyms: cyp19, cyp19a
From
Danio rerio (Zebrafish) (Brachydanio rerio) [TaxID: 7955] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Ovary;
Bauer M.P., Goetz F.W.;
"Isolation and characterization of a zebrafish (Danio rerio) aromatase cDNA.";
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF004521; AAB65788.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_571229.2; -.
UniGene Dr.75765
3D structure databases
ModBase O42145.
Organism-specific databases
ZFIN ZDB-GENE-990415-43; cyp19a1a.
Gene expression databases
ArrayExpress O42145; -.
Ontologies
GO
GO:0016020; Cellular component: membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0020037; Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0050381; Molecular function: unspecific monooxygenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
Genome annotation databases
Ensembl ENSDARG00000041348; Danio rerio. [Contig view]
GeneID 30390; -.
KEGG dre:30390; -.
Phylogenomic databases
HOVERGEN O42145; -.
Other
ProtoNet O42145.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   509  509     Cytochrome P450 19A1a. PRO_0000051967
METAL   456   456        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 509 AA [This is the length of the unprocessed precursor] Molecular weight: 57354 Da [This is the MW of the unprocessed precursor] CRC64: F04532DEA8FDB628 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAGDLLQPCG MKPVRLGEAV VDLLIQRAHN GTERAQDNAC GATATILLLL LCLLLAIRHH 

        70         80         90        100        110        120 
RPHKSHIPGP SFFFGLGPVV SYCRFIWSGI GTASNYYNSK YGDIVRVWIN GEETLILSRS 

       130        140        150        160        170        180 
SAVYHVLRKS LYTSRFGSKL GLQCIGMHEQ GIIFNSNVAL WKKVRAFYAK ALTGPGLQRT 

       190        200        210        220        230        240 
MEICTTSTNS HLDDLSQLTD AQGQLDILNL LRCIVVDVSN RLFLGVPLNE HDLLQKIHKY 

       250        260        270        280        290        300 
FDTWQTVLIK PDVYFRLDWL HRKHKRDAQE LQDAITALIE QKKVQLAHAE KLDHLDFTAE 

       310        320        330        340        350        360 
LIFAQSHGEL SAENVRQCVL EMVIAAPDTL SISLFFMLLL LKQNPDVELK ILQEMDSVLA 

       370        380        390        400        410        420 
GQSLQHSHLS KLQILESFIN ESLRFHPVVD FTMRRALDDD VIEGYNVKKG TNIILNVGRM 

       430        440        450        460        470        480 
HRSEFFSKPN QFSLDNFHKN VPSRFFQPFG SGPRSCVGKH IAMVMMKSIL VALLSRFSVC 

       490        500 
PMKACTVENI PQTNNLSQQP VEEPSSLSV
O42145 in FASTA format

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