ID   APBB3_RAT               Reviewed;         504 AA.
AC   O35827;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-DEC-2008, entry version 50.
DE   RecName: Full=Amyloid beta A4 precursor protein-binding family B member 3;
DE   AltName: Full=Fe65-like protein 2;
DE            Short=Fe65L2;
GN   Name=Apbb3; Synonyms=Fe65l2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=98129769; PubMed=9461550;
RA   Duilio A., Faraonio R., Minopoli G., Zambrano N., Russo T.;
RT   "Fe65L2: a new member of the Fe65 protein family interacting with the
RT   intracellular domain of the Alzheimer's beta-amyloid precursor
RT   protein.";
RL   Biochem. J. 330:513-519(1998).
CC   -!- FUNCTION: May modulate the internalization of beta-amyloid
CC       precursor protein.
CC   -!- SUBUNIT: Binds to the intracellular domain of the beta-amyloid
CC       precursor protein. Also bind to APP-like proteins.
CC   -!- INTERACTION:
CC       P05067:APP (xeno); NbExp=1; IntAct=EBI-286163, EBI-77613;
CC       P08592:App; NbExp=1; IntAct=EBI-286163, EBI-286155;
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in brain and testis.
CC   -!- SIMILARITY: Contains 2 PID domains.
CC   -!- SIMILARITY: Contains 1 WW domain.
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DR   EMBL; Y13413; CAA73837.1; -; mRNA.
DR   RefSeq; NP_446409.1; -.
DR   UniGene; Rn.30067; -.
DR   IntAct; O35827; 2.
DR   PRIDE; O35827; -.
DR   Ensembl; ENSRNOG00000017849; Rattus norvegicus.
DR   GeneID; 117026; -.
DR   KEGG; rno:117026; -.
DR   RGD; 620853; Apbb3.
DR   HOVERGEN; O35827; -.
DR   NextBio; 619797; -.
DR   ArrayExpress; O35827; -.
DR   GermOnline; ENSRNOG00000017849; Rattus norvegicus.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   InterPro; IPR011993; PH_type.
DR   InterPro; IPR006020; PTB_PID.
DR   InterPro; IPR001202; WW_Rsp5_WWP.
DR   Gene3D; G3DSA:2.30.29.30; PH_type; 1.
DR   Pfam; PF00640; PID; 2.
DR   Pfam; PF00397; WW; 1.
DR   SMART; SM00462; PTB; 2.
DR   SMART; SM00456; WW; 1.
DR   PROSITE; PS01179; PID; 2.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   1: Evidence at protein level;
KW   Repeat.
FT   CHAIN         1    504       Amyloid beta A4 precursor protein-binding
FT                                family B member 3.
FT                                /FTId=PRO_0000076056.
FT   DOMAIN       29     61       WW.
FT   DOMAIN      111    278       PID 1.
FT   DOMAIN      283    438       PID 2.
SQ   SEQUENCE   504 AA;  54907 MW;  A49CA9E99BDB3A3A CRC64;
     MLGKDYMLAI ILVNCDDDLW GDQNLEGETG LPPGWRKIRD AAGTYYWHVP SGSTQWQRPT
     WELAEDPGTG KEGIWELRPP KGRSFSSLDS SLNRSNSLTW YNEDSYVRSL EPGAKCFAVR
     SLGWVEVPEE DLAPGKSSIA VNNCIQQLAQ ARNRSQPHDG AWGEGQNMLM VLKKDAMSLL
     NPLDHSLIHC QPLVHIRVWG VGSSKGRDRD FAFVAGDKDS CMLKCHVFRC DVPAKAIASR
     LQGLCAQILS ERVGLSGEAA CCSPDPISPE DFPRQVELLD AVSQAAQKYE ALYMGILPVT
     KAMGMDVLNE AIGTLTGRGD RKTWVPAMLS VSDSLMTAHP IQAEAGAEEE PLWQCPVRLV
     TFIGVGHDPH TFGLIADLGC QSFQCAAFWC QPHAGGLSEA VQAACMVQYQ KCLVASAARG
     KAWGAQARAR LRLKRTSSMD SPGGPLPPPL LKGGVGGAGA APRKRGVFSF LDAFRLKPLF
     SICPKLILEG WGKRLYTLPV PRVL
//