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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Lung;
Kim T.-S.,
Feinstein S.I.,
Dodia C.,
Hennigan B.B.,
Fisher A.B.;
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar;
TISSUE=Olfactory epithelium;
Andreeva S.;
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
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[3]
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PROTEIN SEQUENCE OF 2-41; 57-84; 98-118; 133-142; 156-162 AND 183-199, AND MASS SPECTROMETRY.
STRAIN=Sprague-Dawley;
TISSUE=Hippocampus, and Spinal cord;
Lubec G.,
Afjehi-Sadat L.,
Chen W.-Q.;
Submitted (APR-2007) to UniProtKB.
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[4]
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PROTEIN SEQUENCE OF 26-42 AND 146-163.
DOI=10.1074/jbc.272.4.2542; PubMed=8999971 [NCBI, ExPASy, EBI, Israel, Japan]
Kim T.-S.,
Sundaresh C.S.,
Feinstein S.I.,
Dodia C.,
Skach W.R.,
Jain M.K.,
Nagase T.,
Seki N.,
Ishikawa K.,
Nomura N.,
Fisher A.B.;
"Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein.";
J. Biol. Chem. 272:2542-2550(1997).
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[5]
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ERRATUM.
Kim T.-S.,
Sundaresh C.S.,
Feinstein S.I.,
Dodia C.,
Skach W.R.,
Jain M.K.,
Nagase T.,
Seki N.,
Ishikawa K.,
Nomura N.,
Fisher A.B.;
J. Biol. Chem. 272:10981-10981(1997).
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- FUNCTION: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
- CATALYTIC ACTIVITY: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
- CATALYTIC ACTIVITY: Donor + H2O2 = oxidized donor + 2 H2O.
- SUBUNIT: Homotetramer. May interact with HTR2A. Interacts with STH (By similarity).
- SUBCELLULAR LOCATION: Cytoplasm. Lysosome. Note=Also found in lung secretory organelles.
- MISCELLANEOUS: The active site is the redox-active Cys-47 oxidized to Cys-SOH. Cys-SOH may rapidly react with a Cys-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin (By similarity).
- MISCELLANEOUS: Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress (By similarity).
- SIMILARITY: Belongs to the ahpC/TSA family. Rehydrin subfamily.
- SIMILARITY: Contains 1 thioredoxin domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 224 AA [This is the length of the unprocessed precursor] |
Molecular weight: 24819 Da [This is the MW of the unprocessed precursor] |
CRC64: EE41D9079A708FD9 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MPGGLLLGDE APNFEANTTI GHIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE
70 80 90 100 110 120
FAKRNVKLIA LSIDSVEDHF AWSKDINAYN GAAPTEKLPF PIIDDKDRDL AILLGMLDPA
130 140 150 160 170 180
EKDEKGMPVT ARVVFIFGPD KKLKLSILYP ATTGRNFDEI LRVVDSLQLT ASNPVATPVD
190 200 210 220
WKKGESVMVL PTLPEEEAKQ LFPKGVFTKE LPSGKKYLRY TPQP
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O35244 in FASTA format |
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