ID   BCEA_BACSU              Reviewed;         253 AA.
AC   O34697;
DT   02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-NOV-2008, entry version 48.
DE   RecName: Full=Bacitracin export ATP-binding protein bceA;
GN   Name=bceA; Synonyms=barC, ytsC; OrderedLocusNames=BSU30380;
OS   Bacillus subtilis.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1423;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   MEDLINE=98048467; PubMed=9387221;
RA   Lapidus A., Galleron N., Sorokin A., Ehrlich S.-D.;
RT   "Sequencing and functional annotation of the Bacillus subtilis genes
RT   in the 200 kb rrnB-dnaB region.";
RL   Microbiology 143:3431-3441(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   MEDLINE=98044033; PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA   Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA   Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA   Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA   Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA   Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T.,
RA   Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA   Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA   Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA   Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA   Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA   Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA   Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA   Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA   Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA   Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA   Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA   Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA   Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA   Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA   Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA   Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   INDUCTION, AND PROBABLE FUNCTION.
RC   STRAIN=168;
RX   MEDLINE=22973983; PubMed=14612242; DOI=10.1016/S0378-1097(03)00738-9;
RA   Bernard R., Joseph P., Guiseppi A., Chippaux M., Denizot F.;
RT   "YtsCD and YwoA, two independent systems that confer bacitracin
RT   resistance to Bacillus subtilis.";
RL   FEMS Microbiol. Lett. 228:93-97(2003).
RN   [4]
RP   INDUCTION, AND PROBABLE FUNCTION.
RC   STRAIN=168;
RX   MEDLINE=22773320; PubMed=12890034;
RX   DOI=10.1046/j.1365-2958.2003.03653.x;
RA   Ohki R., Giyanto X., Tateno K., Masuyama W., Moriya S., Kobayashi K.,
RA   Ogasawara N.;
RT   "The BceRS two-component regulatory system induces expression of the
RT   bacitracin transporter, BceAB, in Bacillus subtilis.";
RL   Mol. Microbiol. 49:1135-1144(2003).
RN   [5]
RP   INDUCTION.
RC   STRAIN=168 / CU1065;
RX   PubMed=14651641; DOI=10.1046/j.1365-2958.2003.03786.x;
RA   Mascher T., Margulis N.G., Wang T., Ye R.W., Helmann J.D.;
RT   "Cell wall stress responses in Bacillus subtilis: the regulatory
RT   network of the bacitracin stimulon.";
RL   Mol. Microbiol. 50:1591-1604(2003).
CC   -!- FUNCTION: Part of the ABC transporter complex bceAB
CC       (TC 3.A.1.123.5) involved in bacitracin export. Responsible for
CC       energy coupling to the transport system.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins
CC       (bceA) and two transmembrane proteins (bceB) (Probable).
CC   -!- INDUCTION: Expression is induced by bacitracin, via the two-
CC       component regulatory system bceS/bceR.
CC   -!- SIMILARITY: Belongs to the ABC transporter family.
CC   -!- SIMILARITY: Contains 1 ABC transporter domain.
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DR   EMBL; AF008220; AAC00255.1; -; Genomic_DNA.
DR   EMBL; Z99119; CAB15016.1; -; Genomic_DNA.
DR   PIR; A70001; A70001.
DR   RefSeq; NP_390916.1; -.
DR   HSSP; Q58206; 1L2T.
DR   GeneID; 937246; -.
DR   GenomeReviews; AL009126_GR; BSU30380.
DR   KEGG; bsu:BSU30380; -.
DR   NMPDR; fig|224308.1.peg.3041; -.
DR   SubtiList; BG13920; bceA.
DR   HOGENOM; O34697; -.
DR   BioCyc; BSUB224308:BSU3033-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003593; AAA+_ATPase_core.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   Pfam; PF00005; ABC_tran; 1.
DR   ProDom; PD000006; ABC_transporter; 1.
DR   SMART; SM00382; AAA; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; FALSE_NEG.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic resistance; ATP-binding; Complete proteome;
KW   Nucleotide-binding; Transport.
FT   CHAIN         1    253       Bacitracin export ATP-binding protein
FT                                bceA.
FT                                /FTId=PRO_0000091945.
FT   DOMAIN        4    243       ABC transporter.
FT   NP_BIND      40     47       ATP (Potential).
SQ   SEQUENCE   253 AA;  28234 MW;  95D28581A96627AA CRC64;
     MVILEANKIR KSYGNKLNKQ EVLKGIDIHI EKGEFVSIMG ASGSGKTTLL NVLSSIDQVS
     HGTIHINGND MTAMKEKQLA EFRKQHLGFI FQDYNLLDTL TVKENILLPL SITKLSKKEA
     NRKFEEVAKE LGIYELRDKY PNEISGGQKQ RTSAGRAFIH DPSIIFADEP TGALDSKSAS
     DLLNKLSQLN QKRNATIIMV THDPVAASYC GRVIFIKDGQ MYTQLNKGGQ DRQTFFQDIM
     KTQGVLGGVQ HEH
//