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UniProtKB/Swiss-Prot entry O29610

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH_ARCFU
Primary accession number O29610
Secondary accession number O31221
Integrated into Swiss-Prot on August 29, 2001
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 71)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: icd
OrderedLocusNames: AF_0647
From
Archaeoglobus fulgidus [TaxID: 2234] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae; Archaeoglobus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-27, AND CHARACTERIZATION.
STRAIN=ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126;
DOI=10.1007/s002030050516; PubMed=9325430 [NCBI, ExPASy, EBI, Israel, Japan]
Steen I.H., Lien T., Birkeland N.-K.;
"Biochemical and phylogenetic characterization of isocitrate dehydrogenase from a hyperthermophilic archaeon, Archaeoglobus fulgidus.";
Arch. Microbiol. 168:412-420(1997).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126;
DOI=10.1038/37052; PubMed=9389475 [NCBI, ExPASy, EBI, Israel, Japan]
Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus.";
Nature 390:364-370(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z96105; CAB09535.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000782; AAB90591.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G69330; G69330.
RefSeq NP_069481.1; -.
3D structure databases
PDB
2IV0; X-ray; 2.50 A; A/B=1-412.[ExPASy / RCSB / EBI]
PDBsum 2IV0; -.
ModBase O29610.
Enzyme and pathway databases
BioCyc AFUL224325:AF_0647-MON; -.
Ontologies
GO
GO:0004450; Molecular function: isocitrate dehydrogenase (NADP+) activity (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006097; Biological process: glyoxylate cycle (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR004439; IsoCit_DHase_NADP_prok.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF1; NADP_IDH_prok; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00183; prok_nadp_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
Genome annotation databases
GeneID 1483865; -.
GenomeReviews AE000782_GR; AF_0647.
KEGG afu:AF0647; -.
NMPDR fig|224325.1.peg.640; -.
TIGR AF_0647; -.
Phylogenomic databases
HOGENOM O29610; -.
Other
ProtoNet O29610.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Complete proteome; Direct protein sequencing; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   412  412     Isocitrate dehydrogenase [NADP]. PRO_0000083572
NP_BIND   333   339  7     NADP (By similarity). 
METAL   301   301        Magnesium or manganese (By similarity). 
BINDING   100   100        NADP (By similarity). 
BINDING   109   109        Substrate (By similarity). 
BINDING   111   111        Substrate (By similarity). 
BINDING   115   115        Substrate (By similarity). 
BINDING   125   125        Substrate (By similarity). 
BINDING   149   149        Substrate (By similarity). 
BINDING   346   346        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
BINDING   385   385        NADP (By similarity). 
BINDING   389   389        NADP (By similarity). 
SITE   156   156  1     Critical for catalysis (By similarity). 
SITE   223   223  1     Critical for catalysis (By similarity). 
MOD_RES   109   109        Phosphoserine (By similarity). 
STRAND   16    18  3      
STRAND   21    23  3      
STRAND   26    33  8      
HELIX   39    57  19      
STRAND   62    65  4      
HELIX   70    76  7      
HELIX   82    91  10      
STRAND   93    96  4      
STRAND   103   108  6      
HELIX   109   117  9      
STRAND   122   128  7      
STRAND   136   138  3      
HELIX   140   142  3      
STRAND   144   150  7      
STRAND   152   154  3      
HELIX   155   157  3      
HELIX   166   179  14      
HELIX   196   212  17      
STRAND   216   222  7      
TURN   224   226  3      
TURN   228   230  3      
HELIX   231   245  15      
TURN   247   249  3      
HELIX   253   260  8      
STRAND   269   275  7      
HELIX   276   278  3      
HELIX   279   285  7      
HELIX   287   289  3      
STRAND   292   295  4      
HELIX   297   310  14      
HELIX   314   316  3      
STRAND   318   323  6      
STRAND   326   333  8      
TURN   338   341  4      
HELIX   348   360  13      
HELIX   364   379  16      
HELIX   385   391  7      
STRAND   393   395  3      
HELIX   398   411  14      
Sequence information
Length: 412 AA [This is the length of the unprocessed precursor] Molecular weight: 45842 Da [This is the MW of the unprocessed precursor] CRC64: A2E1A3AA7662D3EA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQYEKVKPPE NGEKIRYENG KLIVPDNPII PYFEGDGIGK DVVPAAIRVL DAAADKIGKE 

        70         80         90        100        110        120 
VVWFQVYAGE DAYKLYGNYL PDDTLNAIKE FRVALKGPLT TPVGGGYRSL NVTIRQVLDL 

       130        140        150        160        170        180 
YANVRPVYYL KGVPSPIKHP EKVNFVIFRE NTEDVYAGIE WPRGSEEALK LIRFLKNEFG 

       190        200        210        220        230        240 
VTIREDSGIG IKPISEFATK RLVRMAIRYA IENNRKSVTL VHKGNIMKYT EGAFRDWGYE 

       250        260        270        280        290        300 
VAKQEFGEYC ITEDELWDKY GGKQPEGKIV VKDRIADNMF QQILTRTDEY DVIALPNLNG 

       310        320        330        340        350        360 
DYLSDAAAAL IGGLGIAPGS NIGDGIGVFE PVHGSAPKYA GQNKVNPTAE ILTGALMFEY 

       370        380        390        400        410 
IGWKDASEMI KKAVEMTISS GIVTYDIHRH MGGTKVGTRE FAEAVVENLQ SL
O29610 in FASTA format

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