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UniProtKB/Swiss-Prot entry O28766

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHAS_ARCFU
Primary accession number O28766
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 56)
Name and origin of the protein
Protein name Aspartate-semialdehyde dehydrogenase
Synonyms ASA dehydrogenase
ASADH
EC 1.2.1.11
Gene name
Name: asd
OrderedLocusNames: AF_1506
From
Archaeoglobus fulgidus [TaxID: 2234] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae; Archaeoglobus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126;
DOI=10.1038/37052; PubMed=9389475 [NCBI, ExPASy, EBI, Israel, Japan]
Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus.";
Nature 390:364-370(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000782; AAB89738.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A69438; A69438.
RefSeq NP_070335.1; -.
3D structure databases
ModBase O28766.
Enzyme and pathway databases
BioCyc AFUL224325:AF_1506-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0004073; Molecular function: aspartate-semialdehyde dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0046983; Molecular function: protein dimerization activity (inferred from electronic annotation from InterPro).
GO:0009086; Biological process: methionine biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0009088; Biological process: threonine biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000319; Asp-semialdehyde_DHase_CS.
IPR005676; Asp_semi-ald_DHase_pep-lack.
IPR012080; Asp_semialdehyde_DHase.
IPR000534; Semialdehyde_DHase_NAD-bd.
IPR012280; Semialdhyde_DHase_C.
Graphical view of domain structure.
Pfam PF01118; Semialdhyde_dh; 1.
PF02774; Semialdhyde_dhC; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000148; ASA_dh; 1.
TIGRFAMs TIGR00978; asd_EA; 1.
PROSITE PS01103; ASD; 1.
Genome annotation databases
GeneID 1484733; -.
GenomeReviews AE000782_GR; AF_1506.
KEGG afu:AF1506; -.
NMPDR fig|224325.1.peg.1496; -.
TIGR AF_1506; -.
Phylogenomic databases
HOGENOM O28766; -.
Other
ProtoNet O28766.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Methionine biosynthesis; NADP; Oxidoreductase; Threonine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   343  343     Aspartate-semialdehyde dehydrogenase. PRO_0000141396
ACT_SITE   148   148        Acyl-thioester intermediate (By similarity). 
Sequence information
Length: 343 AA [This is the length of the unprocessed precursor] Molecular weight: 37697 Da [This is the MW of the unprocessed precursor] CRC64: A6C9F5D045CBFC21 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRYSVGVLGA TGMVGQKFIQ MLAEHPWFKL TSLAASERRV GKKYGEEVDW IVSREVPDIA 

        70         80         90        100        110        120 
KDIEMVPMDP KHVDADIVFS ALPSDIAREV EPKFAEAGFV VASNASAYRM AEDVPLVIPE 

       130        140        150        160        170        180 
VNPEHLGLIE VQKKNRGWDG FIVTNPNCTT IVLVLSLKPL MDLGLRTVRV ASMQALSGAG 

       190        200        210        220        230        240 
YPGVPSLAIT DNVIPFIKGE EDKVEEEPLK LLGKFNGRKI EFADIKVSAS CHRVPVIDGH 

       250        260        270        280        290        300 
TEAVWVEFDR EVSVEEAKAA FESLKPLDLP TSPEKVIIVR EEPDRPQPRL DRDAGNGMSI 

       310        320        330        340 
TVGRIRKDGE RGLKYIVLGH NTVRGAAGAS ILNAELMIKE KII
O28766 in FASTA format

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