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UniProtKB/Swiss-Prot entry O28034

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_ARCFU
Primary accession number O28034
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 61)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: AF_2250
From
Archaeoglobus fulgidus [TaxID: 2234] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae; Archaeoglobus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126;
DOI=10.1038/37052; PubMed=9389475 [NCBI, ExPASy, EBI, Israel, Japan]
Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus.";
Nature 390:364-370(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000782; AAB89007.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B69531; B69531.
RefSeq NP_071075.1; -.
3D structure databases
ModBase O28034.
Enzyme and pathway databases
BioCyc AFUL224325:AF_2250-MON; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
Genome annotation databases
GeneID 1485481; -.
GenomeReviews AE000782_GR; AF_2250.
KEGG afu:AF2250; -.
NMPDR fig|224325.1.peg.2236; -.
TIGR AF_2250; -.
Phylogenomic databases
HOGENOM O28034; -.
Other
ProtoNet O28034.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   403  403     Dihydroorotase. PRO_0000147267
METAL   48    48        Zinc 1 (By similarity). 
METAL   50    50        Zinc 1 (By similarity). 
METAL   172   172        Zinc 2 (By similarity). 
METAL   211   211        Zinc 2 (By similarity). 
METAL   277   277        Zinc 1 (By similarity). 
Sequence information
Length: 403 AA [This is the length of the unprocessed precursor] Molecular weight: 45559 Da [This is the MW of the unprocessed precursor] CRC64: 7AF4E74CCA4624AF [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MIRGKVFYKG EFVEAGIEVE NGRIKRIGKL VEGKEVKGVI LPAGIDVHVH LRDFAEKRKE 

        70         80         90        100        110        120 
TIETGTLSAL HGGICLVVDQ PNTKPPVDDA ETYFRRMGKA EKSVYVDYAL NLALTNSNHG 

       130        140        150        160        170        180 
KIGSIMRKIS ERYFVPAVGE VFIQHDSEDL QIDYETLSSV YKRFEGVVFT IHAEDPAYVA 

       190        200        210        220        230        240 
RGSPNFVFRR REAEVLAVER LVELGKFHFC HISTKDSAKE ILNSNSTYEV TPHHMLLSVE 

       250        260        270        280        290        300 
DYGRLGNLVN VNPPLRERED VEWLFRNFHR IDVLASDHAP HTLEDKEAGA SGFPGVETMY 

       310        320        330        340        350        360 
PLFVNLASKG YISFKTLVEK IASNPARIFG FKGYGEIEVG NYANFAVFDL KKVDEIRAER 

       370        380        390        400 
LHSKCGWTPF EGFEAVFPDK VYLRGKELLE NEMKAGNVLK KRV
O28034 in FASTA format

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