FUNCTION: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
CATALYTIC ACTIVITY: Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.
SUBUNIT: Heterodimer of a large subunit and a small subunit (By similarity).
SIMILARITY: Belongs to the archaeal DNA polymerase II family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE000666; AAB86010.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

H69071; H69071.

RefSeq

NP_276649.1; -.

3D structure databases

ModBase

O27579.

Enzyme and pathway databases

BioCyc

MTHE187420:MTH1536-MON; -.

Ontologies

GO:0008408;	Molecular function: 3'-5' exonuclease activity (inferred from electronic annotation from HAMAP).
GO:0003677;	Molecular function: DNA binding (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0000738;	Biological process: DNA catabolic process, exonucleolytic (inferred from electronic annotation from HAMAP).
GO:0006261;	Biological process: DNA-dependent DNA replication (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00324; -; 1.
PBIL [Tree]

InterPro

IPR004475; PolC_DP2.
IPR016033; PolC_DP2_N.
Graphical view of domain structure.

Pfam

PF03833; PolC_DP2; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF016275; PolC_DP2; 1.

TIGRFAMs

TIGR00354; polC; 1.

Genome annotation databases

GeneID

1471805; -.

GenomeReviews

AE000666_GR; MTH_1536.

KEGG

mth:MTH1536; -.

NMPDR

fig|187420.1.peg.1504; -.

Phylogenomic databases

HOGENOM

O27579; -.

Genome annotation databases

CMR

O27579; MTH_1536.

Other

ProtoNet

O27579.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; DNA replication; DNA-binding; DNA-directed DNA polymerase; Exonuclease; Hydrolase; Multifunctional enzyme; Nuclease; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1092`	`1092`		`DNA polymerase II large subunit.`	`PRO_0000152578`

Sequence information

Length: 1092 AA [This is the length of the unprocessed precursor]

Molecular weight: 123060 Da [This is the MW of the unprocessed precursor]

CRC64: AA6970F7A6F42DFF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MMDYFNELER ETERLYEIAR KARARGLDVS TTPEIPLAKD LAERVEGLVG PEGIARRIKE 

        70         80         90        100        110        120 
LEGDRGREEV AFQIAAEIAS QAVPDDDPEE REKLADQALR TALAILTEGV VAAPLEGIAR 

       130        140        150        160        170        180 
VRIKENFDKS RYLAVYFAGP IRSAGGTAAA LSVLIADYIR LAVGLDRYKP VEREIERYVE 

       190        200        210        220        230        240 
EVELYESEVT NLQYSPKPDE VRLAASKIPV EVTGEPTDKV EVSHRDLERV ETNNIRGGAL 

       250        260        270        280        290        300 
LAMVEGVIQK APKVLKYAKQ LKLEGWDWLE KFSKAPKKGE GEEKVVVKAD SKYVEDIIGG 

       310        320        330        340        350        360 
RPVLAYPSEK GAFRLRYGRA RNTGLAAMGV HPATMELLQF LAVGTQMKIE RPGKGNCVVP 

       370        380        390        400        410        420 
VDTIDGPVVK LRNGDVIRIE DAETASRVRS EVEEILFLGD MLVAFGEFLR NNHVLMPAGW 

       430        440        450        460        470        480 
CEEWWIQTIL SSPKYPGDDP LNLSYYRTRW NELEVSAGDA FRISEEYDVP LHPRYTYFYH 

       490        500        510        520        530        540 
DVTVRELNML REWLNTSQLE DELVLELRPE KRILEILGVP HRVKDSRVVI GHDDAHALIK 

       550        560        570        580        590        600 
TLRKPLEDSS DTVEALNRVS PVRIMKKAPT YIGTRVGRPE KTKERKMRPA PHVLFPIGKY 

       610        620        630        640        650        660 
GGSRRNIPDA AKKGSITVEI GRATCPSCRV SSMQSICPSC GSRTVIGEPG KRNINLAALL 

       670        680        690        700        710        720 
KRAAENVSVR KLDEIKGVEG MISAEKFPEP LEKGILRAKN DVYTFKDATI RHDSTDLPLT 

       730        740        750        760        770        780 
HFTPREVGVS VERLRELGYT RDCYGDELED EDQILELRVQ DVVISEDCAD YLVRVANFVD 

       790        800        810        820        830        840 
DLLERFYDLE RFYNVKTRED LVGHLIAGLA PHTSAAVLGR IIGFTGASAC YAHPYFHSAK 

       850        860        870        880        890        900 
RRNCDSDEDS VMLLLDALLN FSKSYLPSSR GGSMDAPLVL STRIDPEEID DESHNIDTMD 

       910        920        930        940        950        960 
MIPLEVYERS FDHPRPSEVL DVIDNVEKRL GKPEQYTGLM FSHNTSRIDE GPKVCLYKLL 

       970        980        990       1000       1010       1020 
PTMKEKVESQ ITLAEKIRAV DQRSVVEGVL MSHFLPDMMG NIRAFSRQKV RCTKCNRKYR 

      1030       1040       1050       1060       1070       1080 
RIPLSGECRC GGNLVLTVSK GSVIKYLEIS KELASRYPID PYLMQRIEIL EYGVNSLFES 

      1090 
DRSKQSSLDV FL

O27579 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools