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UniProtKB/Swiss-Prot entry O26801

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name VORA_METTH
Primary accession number O26801
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 51)
Name and origin of the protein
Protein name Ketoisovalerate oxidoreductase subunit vorA
Synonyms VOR
EC 1.2.7.7
2-oxoisovalerate oxidoreductase alpha chain
2-oxoisovalerate ferredoxin reductase subunit alpha
Gene name
Name: vorA
OrderedLocusNames: MTH_705
From
Methanobacterium thermoautotrophicum [TaxID: 187420] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Delta H;
PubMed=9371463 [NCBI, ExPASy, EBI, Israel, Japan]
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R., Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.;
"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics.";
J. Bacteriol. 179:7135-7155(1997).
Comments
  • CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
  • SUBUNIT: Heterotrimer of the vorA, vorB and vorC subunits (By similarity).
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000666; AAB85210.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B69194; B69194.
RefSeq NP_275848.1; -.
3D structure databases
ModBase O26801.
Enzyme and pathway databases
BioCyc MTHE187420:MTH705-MON; -.
Ontologies
GO
GO:0043807; Molecular function: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity (inferred from electronic annotation from EC).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0030976; Molecular function: thiamin pyrophosphate binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002869; Pyrv_Fd/Flavodoxin_OxRdtase.
IPR011766; TPP_enzyme_bd_C.
Graphical view of domain structure.
Gene3D G3DSA:3.40.920.10; Pyrv_Fd/Flavodoxin_OxRdtase; 1.
Pfam PF01558; POR; 1.
PF02775; TPP_enzyme_C; 1.
Pfam graphical view of domain structure.
Genome annotation databases
GeneID 1470666; -.
GenomeReviews AE000666_GR; MTH_705.
KEGG mth:MTH705; -.
NMPDR fig|187420.1.peg.703; -.
Phylogenomic databases
HOGENOM O26801; -.
Other
LinkHub O26801; -.
Genome annotation databases
CMR O26801; MTH_705.
Other
ProtoNet O26801.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   477  476     Ketoisovalerate oxidoreductase subunit vorA. PRO_0000099949
Sequence information
Length: 477 AA [This is the length of the unprocessed precursor] Molecular weight: 51628 Da [This is the MW of the unprocessed precursor] CRC64: FFDF19226C40790A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTKKVIRKPD SLHDVFERKG GSAPTATHYC AGCGHGILHK LIGEAMDELG IQERAVMISP 

        70         80         90        100        110        120 
VGCAVFAYYY FDCGNVQVAH GRAPAVGTGI SRAEDDAVVI LYQGDGDLAS IGLNETIQAA 

       130        140        150        160        170        180 
NRGEKLAVFF VNNTVYGMTG GQMAPTTLVG EVTVTCPTGR DPRYAGYPLH MCELLDNLQA 

       190        200        210        220        230        240 
PVFIERVSLA DPKRIRRARR AIKRALEIQR DGKGYAFVEV LSPCPTNLRQ DAEGAERFLK 

       250        260        270        280        290        300 
EEMEKEFPVK NFRDRSAETE PLIRSESDFS RESLDRIFQI REDSVPDPVD DPEFPEVRVK 

       310        320        330        340        350        360 
IAGFGGQGVL SMGLTLAQAA CSEGRHTSWY PAYGPEQRGG TSSCGVVISG ERVGSPAVDT 

       370        380        390        400        410        420 
PDVLVALNQP SLDEFADDVA DGGIILYDST TASFSGGAVR AMGVPALEIA RKHGTARAAN 

       430        440        450        460        470 
TVMLGVMMAL GLTGLDEESF REAIKFTFAG KEKIIDMNLR ILEAGAEWAR ENIEGEL
O26801 in FASTA format

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