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UniProtKB/Swiss-Prot entry O24990

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FABI_HELPY
Primary accession number O24990
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 61)
Name and origin of the protein
Protein name Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms EC 1.3.1.9
NADH-dependent enoyl-ACP reductase
Gene name
Name: fabI
OrderedLocusNames: HP_0195
From
Helicobacter pylori (Campylobacter pylori) [TaxID: 210] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700392 / 26695;
DOI=10.1038/41483; PubMed=9252185 [NCBI, ExPASy, EBI, Israel, Japan]
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
"The complete genome sequence of the gastric pathogen Helicobacter pylori.";
Nature 388:539-547(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000511; AAD07262.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C64544; C64544.
RefSeq NP_206994.1; -.
3D structure databases
PDB
2PD3; X-ray; 2.50 A; A/B/C/D=1-275.[ExPASy / RCSB / EBI]
2PD4; X-ray; 2.30 A; A/B/C/D=1-275.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 2PD3; -.
2PD4; -.
ModBase O24990.
Ontologies
GO
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004318; Molecular function: enoyl-[acyl-carrier-protein] reductase (NADH) activity (inferred from electronic annotation from InterPro).
GO:0006633; Biological process: fatty acid biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR014358; Enoyl-ACP_rdct.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
PTHR19410:SF12; Enoyl-ACP_rdct; 1.
PRINTS PR00081; GDHRDH.
Genome annotation databases
GeneID 899156; -.
GenomeReviews AE000511_GR; HP_0195.
KEGG hpy:HP0195; -.
NMPDR fig|85962.1.peg.192; -.
TIGR HP_0195; -.
Phylogenomic databases
HOGENOM O24990; -.
Other
ProtoNet O24990.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cell inner membrane; Cell membrane; Complete proteome; Fatty acid biosynthesis; Lipid synthesis; Membrane; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   275  275     Enoyl-[acyl-carrier-protein] reductase [NADH]. PRO_0000054902
NP_BIND   10    36  27     NAD (By similarity). 
BINDING   155   155        Substrate (By similarity). 
TURN   3     6  4      
STRAND   8    12  5      
HELIX   20    29  10      
TURN   30    32  3      
STRAND   34    41  8      
TURN   42    44  3      
HELIX   45    54  10      
STRAND   60    62  3      
HELIX   68    81  14      
STRAND   85    90  6      
HELIX   97   100  4      
HELIX   104   106  3      
HELIX   109   119  11      
HELIX   121   130  10      
HELIX   131   133  3      
STRAND   134   144  11      
HELIX   146   148  3      
HELIX   156   177  22      
TURN   178   180  3      
STRAND   182   188  7      
HELIX   196   198  3      
HELIX   202   212  11      
HELIX   221   232  12      
HELIX   234   236  3      
STRAND   243   247  5      
HELIX   250   252  3      
STRAND   253   255  3      
TURN   262   265  4      
HELIX   268   271  4      
Sequence information
Length: 275 AA [This is the length of the unprocessed precursor] Molecular weight: 29981 Da [This is the MW of the unprocessed precursor] CRC64: 1894A5AA2105895A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGFLKGKKGL IVGVANNKSI AYGIAQSCFN QGATLAFTYL NESLEKRVRP IAQELNSPYV 

        70         80         90        100        110        120 
YELDVSKEEH FKSLYNSVKK DLGSLDFIVH SVAFAPKEAL EGSLLETSKS AFNTAMEISV 

       130        140        150        160        170        180 
YSLIELTNTL KPLLNNGASV LTLSYLGSTK YMAHYNVMGL AKAALESAVR YLAVDLGKHH 

       190        200        210        220        230        240 
IRVNALSAGP IRTLASSGIA DFRMILKWNE INAPLRKNVS LEEVGNAGMY LLSSLSSGVS 

       250        260        270 
GEVHFVDAGY HVMGMGAVEE KDNKATLLWD LHKEQ
O24990 in FASTA format

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