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UniProtKB/Swiss-Prot entry O23920

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HPPD_DAUCA
Primary accession number O23920
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 57)
Name and origin of the protein
Protein name 4-hydroxyphenylpyruvate dioxygenase
Synonyms EC 1.13.11.27
4-hydroxyphenylpyruvic acid oxidase
HPPDase
4HPPD
HPD
Gene name None
From
Daucus carota (Carrot) [TaxID: 4039] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; asterids; campanulids; Apiales; Apiaceae; Apioideae; Scandiceae; Daucinae; Daucus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9271098 [NCBI, ExPASy, EBI, Israel, Japan]
Garcia I., Rodgers M., Lenne C., Rolland A., Sailland A., Matringe M.;
"Subcellular localization and purification of a p-hydroxyphenylpyruvate dioxygenase from cultured carrot cells and characterization of the corresponding cDNA.";
Biochem. J. 325:761-769(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U87257; AAC49815.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T14353; T14353.
3D structure databases
SMR O23920; 32-430.
ModBase O23920.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0003868; Molecular function: 4-hydroxyphenylpyruvate dioxygenase activity (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006559; Biological process: L-phenylalanine catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006572; Biological process: tyrosine catabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR005956; 4OHPhenylPyrv_dOase.
IPR004360; Glyas_bleo-R_dOase.
Graphical view of domain structure.
PANTHER PTHR11959; HPP_dOase; 1.
Pfam PF00903; Glyoxalase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF009283; HPP_dOase; 1.
TIGRFAMs TIGR01263; 4HPPD; 1.
Other
ProtoNet O23920.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   442  442     4-hydroxyphenylpyruvate dioxygenase. PRO_0000088398
METAL   219   219        Iron (By similarity). 
METAL   301   301        Iron (By similarity). 
METAL   387   387        Iron (By similarity). 
Sequence information
Length: 442 AA [This is the length of the unprocessed precursor] Molecular weight: 48148 Da [This is the MW of the unprocessed precursor] CRC64: A484AFFA267F7BF7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGKKQSEAEI LSSNSSNTSP ATFKLVGFNN FVRANPKSDH FAVKRFHHIE FWCGDATNTS 

        70         80         90        100        110        120 
RRFSWGLGMP LVAKSDLSTG NSVHASYLVR SANLSFVFTA PYSPSTTTSS GSAAIPSFSA 

       130        140        150        160        170        180 
SGFHSFAAKH GLAVRAIALE VADVAAAFEA SVARGARPAS APVELDDQAW LAEVELYGDV 

       190        200        210        220        230        240 
VLRFVSFGRE EGLFLPGFEA VEGTASFPDL DYGIRRLDHA VGNVTELGPV VEYIKGFTGF 

       250        260        270        280        290        300 
HEFAEFTAED VGTLESGLNS VVLANNEEMV LLPLNEPVYG TKRKSQIQTY LEHNEGAGVQ 

       310        320        330        340        350        360 
HLALVSEDIF RTLREMRKRS CLGGFEFMPS PPPTYYKNLK NRVGDVLSDE QIKECEDLGI 

       370        380        390        400        410        420 
LVDRDDQGTL LQIFTKPVGD RPTLFIEIIQ RVGCMLKDDA GQMYQKGGCG GFGKGNFSEL 

       430        440 
FKSIEEYEKT LEAKQITGSA AA
O23920 in FASTA format

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View entry in raw text format (no links)
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