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UniProtKB/Swiss-Prot entry O21270

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NDUS2_RECAM
Primary accession number O21270
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 52)
Name and origin of the protein
Protein name NADH-ubiquinone oxidoreductase 49 kDa subunit
Synonyms EC 1.6.5.3
EC 1.6.99.3
NADH dehydrogenase subunit 7
Gene name
Name: NAD7
From
Reclinomonas americana [TaxID: 48483] 
Encoded on Mitochondrion.
Taxonomy Eukaryota; Jakobida; Histionidae; Reclinomonas.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 50394;
DOI=10.1038/387493a0; PubMed=9168110 [NCBI, ExPASy, EBI, Israel, Japan]
Lang B.F., Burger G., O'Kelly C.J., Cedergren R., Golding G.B., Lemieux C., Sankoff D., Turmel M., Gray M.W.;
"An ancestral mitochondrial DNA resembling a eubacterial genome in miniature.";
Nature 387:493-497(1997).
Comments
  • FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.
  • CATALYTIC ACTIVITY: NADH + ubiquinone = NAD+ + ubiquinol.
  • CATALYTIC ACTIVITY: NADH + acceptor = NAD+ + reduced acceptor.
  • SUBCELLULAR LOCATION: Mitochondrion.
  • SIMILARITY: Belongs to the complex I 49 kDa subunit family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF007261; AAD11897.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S78164; S78164.
RefSeq NP_044782.1; -.
3D structure databases
ModBase O21270.
Ontologies
GO
GO:0005746; Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0008137; Molecular function: NADH dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR014029; NADH-UbQ_OxRdtase_49kDa_CS.
IPR010219; NADH_DH_1_dsu.
IPR001135; NADH_UbQ_OxRdtase_49kDa.
Graphical view of domain structure.
Pfam PF00346; Complex1_49kDa; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01962; NuoD; 1.
PROSITE PS00535; COMPLEX1_49K; 1.
Genome annotation databases
GeneID 801113; -.
Other
ProtoNet O21270.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Electron transport; Mitochondrion; NAD; Oxidoreductase; Respiratory chain; Transport; Ubiquinone.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   396  396     NADH-ubiquinone oxidoreductase 49 kDa subunit. PRO_0000118593
Sequence information
Length: 396 AA [This is the length of the unprocessed precursor] Molecular weight: 44993 Da [This is the MW of the unprocessed precursor] CRC64: 252B68E29305F096 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQQKALTKKL KNFTMNFGPQ HPAAHGVLRL VLELNGEVVN RADPHIGLLH RGTEKLIEYK 

        70         80         90        100        110        120 
NYLQALPYFD RLDYVSMMAQ EHAYSLAVEK LLGCEVPKRA QYIRVLFCEI TRILNHLMAV 

       130        140        150        160        170        180 
TTHALDVGAM TPFLWGFEER EKLMEFYERV SGARMHAAYI RPGGVSQDMP MGLSEDIYKF 

       190        200        210        220        230        240 
AKQFGSRIDE IEDVLSSNRI WKQRLVDIGT VSAEEALDWG FSGVMLRGSG IAWDLRKTQP 

       250        260        270        280        290        300 
YDVYDELEFD IPVGTKGDCY DRYLIRVEEM RQSLKLIMQC LNKMPTGVIK VDDKKISPPS 

       310        320        330        340        350        360 
RVDMKDSMEA LIHHFKLYTE GYSVPIGETY TAVEAPKGEF GVYLVSDGSS KPYRCKIKAP 

       370        380        390 
GFSHLQGLNF MSKGHMIADV VTIIGTQDIV FGEVDR
O21270 in FASTA format

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