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UniProtKB/Swiss-Prot entry O19004

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ARAF_PIG
Primary accession number O19004
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 69)
Name and origin of the protein
Protein name A-Raf proto-oncogene serine/threonine-protein kinase
Synonyms EC 2.7.11.1
A-Raf-1
Gene name
Name: ARAF
Synonyms: ARAF1
From
Sus scrofa (Pig) [TaxID: 9823] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Landrace;
TISSUE=Liver;
DOI=10.1007/s003359900473; PubMed=9166601 [NCBI, ExPASy, EBI, Israel, Japan]
Yasue H., Adams L., Ozawa A., Hanazono M., Li N., Lin Z.H., Kusumoto H.;
"Assignment of ARAF1 to porcine chromosome Xp11.2-p13 by fluorescence in situ hybridization.";
Mamm. Genome 8:457-458(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D88385; BAA22379.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_999494.1; -.
UniGene Ssc.2370
3D structure databases
HSSP P04049; 1FAR. [HSSP ENTRY / PDB]
SMR O19004; 20-91, 96-146, 303-576.
ModBase O19004.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0019992; Molecular function: diacylglycerol binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004674; Molecular function: protein serine/threonine kinase activity (inferred from electronic annotation from InterPro).
GO:0005057; Molecular function: receptor signaling protein activity (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0007242; Biological process: intracellular signaling cascade (inferred from electronic annotation from InterPro).
GO:0006468; Biological process: protein amino acid phosphorylation (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR002219; DAG_PE_bd.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR003116; Raf_like_ras_bd.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.
Pfam PF00130; C1_1; 1.
PF00069; Pkinase; 1.
PF02196; RBD; 1.
Pfam graphical view of domain structure.
PRINTS PR00008; DAGPEDOMAIN.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00109; C1; 1.
SM00455; RBD; 1.
SMART graphical view of domain structure.
PROSITE PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 397601; -.
KEGG ssc:397601; -.
Phylogenomic databases
HOVERGEN O19004; -.
Other
LinkHub O19004; -.
ProtoNet O19004.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Kinase; Metal-binding; Nucleotide-binding; Phorbol-ester binding; Phosphoprotein; Proto-oncogene; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   606  606     A-Raf proto-oncogene serine/threonine-protein kinase. PRO_0000085624
DOMAIN   19    91  73     RBD. 
DOMAIN   310   570  261     Protein kinase. 
ZN_FING   98   144  47     Phorbol-ester/DAG-type. 
NP_BIND   316   324  9     ATP (By similarity). 
ACT_SITE   429   429        Proton acceptor (By similarity). 
METAL   99    99        Zinc 1 (By similarity). 
METAL   112   112        Zinc 2 (By similarity). 
METAL   115   115        Zinc 2 (By similarity). 
METAL   125   125        Zinc 1 (By similarity). 
METAL   128   128        Zinc 1 (By similarity). 
METAL   133   133        Zinc 2 (By similarity). 
METAL   136   136        Zinc 2 (By similarity). 
METAL   144   144        Zinc 1 (By similarity). 
BINDING   336   336        ATP (By similarity). 
MOD_RES   186   186        Phosphoserine (By similarity). 
MOD_RES   213   213        Phosphothreonine (By similarity). 
MOD_RES   215   215        Phosphothreonine (By similarity). 
MOD_RES   257   257        Phosphoserine (By similarity). 
MOD_RES   580   580        Phosphoserine (By similarity). 
MOD_RES   582   582        Phosphoserine (By similarity). 
Sequence information
Length: 606 AA [This is the length of the unprocessed precursor] Molecular weight: 67538 Da [This is the MW of the unprocessed precursor] CRC64: 1A7EEB9A5D9DE152 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEPPRGPPAN GAEPSRAVGT VKVYLPNKQR TVVTVRDGMS VYDSLDKALK VRGLNQDCCV 

        70         80         90        100        110        120 
VYRLIKGRKT VTAWDTAIAP LDGEELIVEV LEDVPLTMHN FVRKTFFSLA FCDFCLKFLF 

       130        140        150        160        170        180 
HGFRCQTCGY KFHQHCSSKV PTVCVDMSTN RRQFYHSVQD LSGGSRQHET PSNRPLNEPL 

       190        200        210        220        230        240 
TPQGPSSCTQ HRDPEHFPFP APANAPLQRI RSTSTPNVHM VSTTAPMDSG LVQLTAQSFN 

       250        260        270        280        290        300 
TDAAGNRGGG DGAPRGSPSP ASVSSGRKSP HSKSPSEQRE RKSLADDKKK VKNLGYRDSG 

       310        320        330        340        350        360 
YYWEVPPSEV QLLKRIGTGS FGTVFRGRWH GDVAVKVLKV AQPTAEQAQA FKNEMQVLRK 

       370        380        390        400        410        420 
TRHVNILLFM GFMTRPGFAI ITQWCEGSSL YHHLHVADTR FDMVQLIDVA RQTAQGMDYL 

       430        440        450        460        470        480 
HAKNIIHRDL KSNNIFLHEG LTVKIGDFGL ATVKTRWSGA QPLEQPSGSV LWMAAEVIRM 

       490        500        510        520        530        540 
QDPNPYSFQS DVYAYGVVLY ELMTGSLPYS HIGSRDQIIF MVGRGYLSPD LSKISSNCPK 

       550        560        570        580        590        600 
AMRRLLSDCL KFQREERPLF PQILATIELL QRSLPKIERS ASEPSLHRTQ ADELPACLLS 


AARLVP
O19004 in FASTA format

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