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UniProtKB/Swiss-Prot entry O15254

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACOX3_HUMAN
Primary accession number O15254
Secondary accession number Q96AJ8
Integrated into Swiss-Prot on November 2, 2001
Sequence was last modified on February 20, 2007 (Sequence version 2)
Annotations were last modified on    December 16, 2008 (Entry version 72)
Name and origin of the protein
Protein name Peroxisomal acyl-coenzyme A oxidase 3
Synonyms EC 1.3.3.6
Pristanoyl-CoA oxidase
Branched-chain acyl-CoA oxidase
BRCACox
Gene name
Name: ACOX3
Synonyms: BRCOX, PRCOX
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND FUNCTION.
TISSUE=Liver;
PubMed=9271077 [NCBI, ExPASy, EBI, Israel, Japan]
Vanhooren J.C.T., Marynen P., Mannaerts G.P., van Veldhoven P.P.;
"Evidence for the existence of a pristanoyl-CoA oxidase gene in man.";
Biochem. J. 325:593-599(1997).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y11411; CAA72214.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC017053; AAH17053.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001095137.1; -.
NP_003492.2; -.
UniGene Hs.479122
3D structure databases
HSSP P07872; 1IS2. [HSSP ENTRY / PDB]
ModBase O15254.
PTM databases
PhosphoSite O15254; -.
Organism-specific databases
GeneCards GC04M008486; -.
H-InvDB HIX0004086; -.
HGNC HGNC:121; ACOX3.
GenAtlas ACOX3.
MIM 603402; gene. [NCBI / EBI]
PharmGKB PA24445; -.
GeneCards O15254.
Gene expression databases
ArrayExpress O15254; -.
CleanEx HS_ACOX3; -.
GermOnline ENSG00000087008; Homo sapiens.
Ontologies
GO
GO:0005777; Cellular component: peroxisome (traceable author statement from ProtInc).
GO:0003995; Molecular function: acyl-CoA dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0003997; Molecular function: acyl-CoA oxidase activity (traceable author statement from ProtInc).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0008206; Biological process: bile acid metabolic process (traceable author statement from ProtInc).
GO:0006635; Biological process: fatty acid beta-oxidation (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006091; Acyl-CoA_DHase/Oxase_M.
IPR006090; Acyl-CoA_Oxase/DHase_1.
IPR012258; Acyl-CoA_oxidase.
IPR002655; Acyl_CoA_ox_C.
IPR013786; AcylCoA_DH/ox_N.
IPR013764; AcylCoA_oxidase/DH_1/2_C.
Graphical view of domain structure.
Gene3D G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 2.
PANTHER PTHR10909:SF11; Acyl-CoA_oxidase; 1.
Pfam PF01756; ACOX; 1.
PF00441; Acyl-CoA_dh_1; 1.
PF02770; Acyl-CoA_dh_M; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000168; Acyl-CoA_oxidase; 1.
Proteomics databases
PRIDE O15254; -.
Genome annotation databases
Ensembl ENSG00000087008; Homo sapiens. [Contig view]
GeneID 8310; -.
KEGG hsa:8310; -.
Phylogenomic databases
HOGENOM O15254; -.
HOVERGEN O15254; -.
Other
NextBio 31121; -.
SOURCE ACOX3; Homo sapiens.
ProtoNet O15254.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Oxidoreductase; Peroxisome; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   700  700     Peroxisomal acyl-coenzyme A oxidase 3. PRO_0000204685
MOTIF   698   700  3     Microbody targeting signal (By similarity). 
COMPBIAS   340   343  4     Poly-Glu. 
VAR_SEQ   610   624        GGYFSGEQAGEVLES -> AERRCSCPGRRDRSS (in isoform 2). VSP_023355
VAR_SEQ   625   700        Missing (in isoform 2). VSP_023356
VARIANT   34    34  1     E -> A (in dbSNP:rs12513296 [NCBI]). VAR_030802 
VARIANT   497   497  1     D -> N (in dbSNP:rs13434465 [NCBI]). VAR_030803 
CONFLICT   34    35        EL -> DV (in Ref. 1; CAA72214). 
CONFLICT   44    45        ML -> NV (in Ref. 1; CAA72214). 
CONFLICT   95    95        D -> A (in Ref. 1; CAA72214). 
CONFLICT   365   365        A -> G (in Ref. 1; CAA72214). 
CONFLICT   601   601        S -> K (in Ref. 1; CAA72214). 
Sequence information
Length: 700 AA [This is the length of the unprocessed precursor] Molecular weight: 77629 Da [This is the MW of the unprocessed precursor] CRC64: 40D1CD3DC6A620C1 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MASTVEGGDT ALLPEFPRGP LDAYRARASF SWKELALFTE GEGMLRFKKT IFSALENDPL 

        70         80         90        100        110        120 
FARSPGADLS LEKYRELNFL RCKRIFEYDF LSVEDMFKSP LKVPALIQCL GMYDSSLAAK 

       130        140        150        160        170        180 
YLLHSLVFGS AVYSSGSERH LTYIQKIFRM EIFGCFALTE LSHGSNTKAI RTTAHYDPAT 

       190        200        210        220        230        240 
EEFIIHSPDF EAAKFWVGNM GKTATHAVVF AKLCVPGDQC HGLHPFIVQI RDPKTLLPMP 

       250        260        270        280        290        300 
GVMVGDIGKK LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSPF KDVRQRFGAS 

       310        320        330        340        350        360 
LGSLSSGRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP MQQWRLLPYL 

       370        380        390        400        410        420 
AAVYALDHFS KSLFLDLVEL QRGLASGDRS ARQAELGREI HALASASKPL ASWTTQQGIQ 

       430        440        450        460        470        480 
ECREACGGHG YLAMNRLGVL RDDNDPNCTY EGDNNILLQQ TSNYLLGLLA HQVHDGACFR 

       490        500        510        520        530        540 
SPLKSVDFLD AYPGILDQKF EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG 

       550        560        570        580        590        600 
SSDFEARNKC QVSHGRPLAL AFVELTVVQR FHEHVHQPSV PPSLRAVLGR LSALYALWSL 

       610        620        630        640        650        660 
SRHAALLYRG GYFSGEQAGE VLESAVLALC SQLKDDAVAL VDVIAPPDFV LDSPIGRADG 

       670        680        690        700 
ELYKNLWGAV LQESKVLERA SWWPEFSVNK PVIGSLKSKL
O15254 in FASTA format

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