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UniProtKB/Swiss-Prot entry O14730


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name RIOK3_HUMAN
Primary accession number O14730
Secondary accession number Q8IXN9
Integrated into Swiss-Prot on December 7, 2004
Sequence was last modified on February 20, 2007 (Sequence version 2)
Annotations were last modified on    December 16, 2008 (Entry version 64)
Name and origin of the protein
Protein name Serine/threonine-protein kinase RIO3
Synonyms RIO kinase 3
EC 2.7.11.1
sudD homolog
Gene name
Name: RIOK3
Synonyms: SUDD
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
DOI=10.1016/S0378-1119(98)00115-2; PubMed=9602165 [NCBI, ExPASy, EBI, Israel, Japan]
Anaya P., Evans S.C., Dai C., Lozano G., May G.S.;
"Isolation of the Aspergillus nidulans sudD gene and its human homologue.";
Gene 211:323-329(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03983; PubMed=16177791 [NCBI, ExPASy, EBI, Israel, Japan]
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
"DNA sequence and analysis of human chromosome 18.";
Nature 437:551-555(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-122; SER-127 AND SER-128, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[5]
VARIANTS [LARGE SCALE ANALYSIS] VAL-336; GLN-441 AND LEU-447.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF013591; AAC26080.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC026634; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
BC039729; AAH39729.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_003822.2; -.
UniGene Hs.445511
3D structure databases
ModBase O14730.
Protein-protein interaction databases
IntAct O14730; 8.
PTM databases
PhosphoSite O14730; -.
Organism-specific databases
GeneCards GC18P019287; -.
H-InvDB HIX0014365; -.
HGNC HGNC:11451; RIOK3.
GenAtlas RIOK3.
HPA HPA001620; -.
MIM 603579; gene. [NCBI / EBI]
PharmGKB PA36248; -.
GeneCards O14730.
Gene expression databases
ArrayExpress O14730; -.
CleanEx HS_RIOK3; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from HPA).
GO:0005634; Cellular component: nucleus (inferred from direct assay from HPA).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0004674; Molecular function: protein serine/threonine kinase activity (inferred from electronic annotation from InterPro).
GO:0007059; Biological process: chromosome segregation (traceable author statement from ProtInc).
GO:0006468; Biological process: protein amino acid phosphorylation (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000719; Prot_kinase_core.
IPR000687; RIO_kinase.
IPR017406; Ser/Thr_prot_kinase_Rio3.
Graphical view of domain structure.
Pfam PF01163; RIO1; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF038146; Ser/Thr_PK_RIO3; 1.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00090; RIO; 1.
SMART graphical view of domain structure.
PROSITE PS50011; PROTEIN_KINASE_DOM; FALSE_NEG.
PS01245; RIO1; 1.
PROSITE graphical view of domain structure (profiles).
Proteomics databases
PRIDE O14730; -.
Genome annotation databases
Ensembl ENSG00000101782; Homo sapiens. [Contig view]
GeneID 8780; -.
KEGG hsa:8780; -.
Phylogenomic databases
HOGENOM O14730; -.
HOVERGEN O14730; -.
Other
LinkHub O14730; -.
NextBio 32920; -.
SOURCE RIOK3; Homo sapiens.
ProtoNet O14730.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Serine/threonine-protein kinase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   519  519     Serine/threonine-protein kinase RIO3. PRO_0000213529
DOMAIN   251   519  269     Protein kinase. 
NP_BIND   257   265  9     ATP (By similarity). 
ACT_SITE   406   406        Proton acceptor (By similarity). 
BINDING   290   290        ATP (By similarity). 
MOD_RES   122   122        Phosphotyrosine. 
MOD_RES   127   127        Phosphoserine. 
MOD_RES   128   128        Phosphoserine. 
VAR_SEQ   449   451        Missing (in isoform 2). VSP_012164
VARIANT   336   336  1     L -> V (in dbSNP:rs35401850 [NCBI]). VAR_042355 
VARIANT   441   441  1     R -> Q (in dbSNP:rs33969048 [NCBI]). VAR_042356 
VARIANT   447   447  1     S -> L. VAR_042357 
CONFLICT   325   325        I -> H (in Ref. 1; AAC26080). 
Sequence information
Length: 519 AA [This is the length of the unprocessed precursor] Molecular weight: 59093 Da [This is the MW of the unprocessed precursor] CRC64: 3C3392BAC4ECB912 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDLVGVASPE PGTAAAWGPS KCPWAIPQNT ISCSLADVMS EQLAKELQLE EEAAVFPEVA 

        70         80         90        100        110        120 
VAEGPFITGE NIDTSSDLML AQMLQMEYDR EYDAQLRREE KKFNGDSKVS ISFENYRKVH 

       130        140        150        160        170        180 
PYEDSDSSED EVDWQDTRDD PYRPAKPVPT PKKGFIGKGK DITTKHDEVV CGRKNTARME 

       190        200        210        220        230        240 
NFAPEFQVGD GIGMDLKLSN HVFNALKQHA YSEERRSARL HEKKEHSTAE KAVDPKTRLL 

       250        260        270        280        290        300 
MYKMVNSGML ETITGCISTG KESVVFHAYG GSMEDEKEDS KVIPTECAIK VFKTTLNEFK 

       310        320        330        340        350        360 
NRDKYIKDDF RFKDRFSKLN PRKIIRMWAE KEMHNLARMQ RAGIPCPTVV LLKKHILVMS 

       370        380        390        400        410        420 
FIGHDQVPAP KLKEVKLNSE EMKEAYYQTL HLMRQLYHEC TLVHADLSEY NMLWHAGKVW 

       430        440        450        460        470        480 
LIDVSQSVEP THPHGLEFLF RDCRNVSQFF QKGGVKEALS ERELFNAVSG LNITADNEAD 

       490        500        510 
FLAEIEALEK MNEDHVQKNG RKAASFLKDD GDPPLLYDE 

O14730 in FASTA format

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