[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Cervix carcinoma;
DOI=10.1016/S0092-8674(00)80501-2; PubMed=9267021 [NCBI, ExPASy, EBI, Israel, Japan]
Zou H.,
Henzel W.J.,
Liu X.,
Lutschg A.,
Wang X.;
"Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.";
Cell 90:405-413(1997).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 4 AND 5).
TISSUE=Cervix carcinoma, Heart, and Peripheral blood;
DOI=10.1006/bbrc.1999.1124; PubMed=10441496 [NCBI, ExPASy, EBI, Israel, Japan]
Hahn C.,
Hirsch B.,
Jahnke D.,
Duerkop H.,
Stein H.;
"Three new types of Apaf-1 in mammalian cells.";
Biochem. Biophys. Res. Commun. 261:746-749(1999).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=T-cell;
DOI=10.1074/jbc.274.25.17941; PubMed=10364241 [NCBI, ExPASy, EBI, Israel, Japan]
Saleh A.,
Srinivasula S.M.,
Acharya S.,
Fishel R.,
Alnemri E.S.;
"Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation.";
J. Biol. Chem. 274:17941-17945(1999).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, AND MUTAGENESIS OF LYS-160 AND MET-368.
TISSUE=Kidney;
DOI=10.1093/emboj/18.13.3586; PubMed=10393175 [NCBI, ExPASy, EBI, Israel, Japan]
Hu Y.,
Benedict M.A.,
Ding L.,
Nunez G.;
"Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis.";
EMBO J. 18:3586-3595(1999).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 6), FUNCTION, AND SUBCELLULAR LOCATION.
TISSUE=Prostatic carcinoma;
DOI=10.1016/S0006-291X(03)00995-1; PubMed=12804598 [NCBI, ExPASy, EBI, Israel, Japan]
Ogawa T.,
Shiga K.,
Hashimoto S.,
Kobayashi T.,
Horii A.,
Furukawa T.;
"APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line.";
Biochem. Biophys. Res. Commun. 306:537-543(2003).
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Brain;
DOI=10.1093/dnares/4.5.307; PubMed=9455477 [NCBI, ExPASy, EBI, Israel, Japan]
Ishikawa K.,
Nagase T.,
Nakajima D.,
Seki N.,
Ohira M.,
Miyajima N.,
Tanaka A.,
Kotani H.,
Nomura N.,
Ohara O.;
"Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.";
DNA Res. 4:307-313(1997).
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[7]
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SEQUENCE REVISION.
DOI=10.1093/dnares/9.3.99; PubMed=12168954 [NCBI, ExPASy, EBI, Israel, Japan]
Nakajima D.,
Okazaki N.,
Yamakawa H.,
Kikuno R.,
Ohara O.,
Nagase T.;
"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.";
DNA Res. 9:99-106(2002).
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[8]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 810-864 AND 866-883.
Roberts D.L.,
Dalgleish R.,
Cohen G.M.,
MacFarlane M.;
"The mammalian CED4 homologue, APAF1, exists as two distinct forms in human cells.";
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
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[9]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1-138 (ISOFORMS 1/4/5).
Won M.,
Lee J.-W.,
Ohr H.-H.,
Kim D.-U.,
Chung K.-S.,
Lee M.,
Yoo H.-S.;
"Cloning of variant Apaf1.";
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
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[10]
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APAF-1-MEDIATED OLIGOMERIZATION.
DOI=10.1016/S1097-2765(00)80095-7; PubMed=9651578 [NCBI, ExPASy, EBI, Israel, Japan]
Srinivasula S.M.,
Ahmad M.,
Fernandes-Alnemri T.,
Alnemri E.S.;
"Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.";
Mol. Cell 1:949-957(1998).
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[11]
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INDUCTION BY E2F AND P53.
DOI=10.1038/35078527; PubMed=11389439 [NCBI, ExPASy, EBI, Israel, Japan]
Moroni M.C.,
Hickman E.S.,
Denchi E.L.,
Caprara G.,
Colli E.,
Cecconi F.,
Mueller H.,
Helin K.;
"Apaf-1 is a transcriptional target for E2F and p53.";
Nat. Cell Biol. 3:552-558(2001).
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[12]
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INTERACTION WITH APIP.
DOI=10.1074/jbc.M405747200; PubMed=15262985 [NCBI, ExPASy, EBI, Israel, Japan]
Cho D.-H.,
Hong Y.-M.,
Lee H.-J.,
Woo H.-N.,
Pyo J.-O.,
Mak T.W.,
Jung Y.-K.;
"Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein.";
J. Biol. Chem. 279:39942-39950(2004).
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[13]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-204; SER-238 AND SER-248, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V.,
Blagoev B.,
Gnad F.,
Macek B.,
Kumar C.,
Mortensen P.,
Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
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[14]
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X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 1-97.
DOI=10.1006/jmbi.1999.3177; PubMed=10543941 [NCBI, ExPASy, EBI, Israel, Japan]
Vaughn D.E.,
Rodriguez J.,
Lazebnik Y.,
Joshua-Tor L.;
"Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling.";
J. Mol. Biol. 293:439-447(1999).
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[15]
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STRUCTURE BY NMR OF 1-97.
DOI=10.1038/sj.cdd.4400584; PubMed=10578182 [NCBI, ExPASy, EBI, Israel, Japan]
Day C.L.,
Dupont C.,
Lackmann M.,
Vaux D.L.,
Hinds M.G.;
"Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1.";
Cell Death Differ. 6:1125-1132(1999).
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