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UniProtKB/Swiss-Prot entry O09046


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name OXLA_MOUSE
Primary accession number O09046
Secondary accession numbers Q3T9N9 Q3U7S6 Q3V0K2 Q6Y632 Q6YBV6 Q6YDI8 Q8R2G8 Q9CXK7
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on July 1, 1997 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 77)
Name and origin of the protein
Protein name L-amino-acid oxidase [Precursor]
Synonyms LAAO
LAO
EC 1.4.3.2
Interleukin-4-induced protein 1
IL4-induced protein 1
Protein Fig-1
mFIG1
Gene name
Name: Il4i1
Synonyms: Fig1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
STRAIN=BALB/c, and CBA/J;
DOI=10.1073/pnas.94.6.2507; PubMed=9122225 [NCBI, ExPASy, EBI, Israel, Japan]
Chu C.C., Paul W.E.;
"Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis.";
Proc. Natl. Acad. Sci. U.S.A. 94:2507-2512(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
STRAIN=CBA/J, MRL, and NZW;
Chu C.C., Kim J.A., Gupta N., Yuen G.J., Thomas R.R., George J., Hsueh K.;
"Interleukin-four induced gene-1 polymorphisms correlate with Sle3 autoimmune susceptibility.";
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=C57BL/6J, and NOD;
TISSUE=Bone marrow, Embryonic head, Spleen, and Testis;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE OF 122-289.
STRAIN=BALB/c;
TISSUE=Spleen;
DOI=10.1016/S0161-5890(98)00031-5; PubMed=9798653 [NCBI, ExPASy, EBI, Israel, Japan]
Chu C.C., Paul W.E.;
"Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis.";
Mol. Immunol. 35:487-502(1998).
[5]
CHARACTERIZATION, FUNCTION, GLYCOSYLATION, AND SUBCELLULAR LOCATION.
PubMed=15383589 [NCBI, ExPASy, EBI, Israel, Japan]
Mason J.M., Naidu M.D., Barcia M., Porti D., Chavan S.S., Chu C.C.;
"IL-4-induced gene-1 is a leukocyte L-amino acid oxidase with an unusual acidic pH preference and lysosomal localization.";
J. Immunol. 173:4561-4567(2004).
[6]
ALTERNATIVE PROMOTER USAGE, AND TISSUE SPECIFICITY.
DOI=10.1186/1741-7007-3-16; PubMed=16029492 [NCBI, ExPASy, EBI, Israel, Japan]
Wiemann S., Kolb-Kokocinski A., Poustka A.;
"Alternative pre-mRNA processing regulates cell-type specific expression of the IL4l1 and NUP62 genes.";
BMC Biol. 3:16-16(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U70429; AAB51353.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U70430; AAB51354.1; -; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF538041; AAM15529.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY442170; AAM15530.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY157537; AAO17038.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY157538; AAO17039.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY161348; AAO23118.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY178834; AAO65453.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY442343; AAS00457.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK014297; BAB29253.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK133082; BAE21502.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK150582; BAE29676.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK151030; BAE30047.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK151171; BAE30174.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK152538; BAE31293.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK172393; BAE42981.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U89428; AAC36534.1; -; Other_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U89429; AAC36535.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_034345.1; -.
UniGene Mm.27567
3D structure databases
PDB
2I8W; Model; -; @=30-502.[ExPASy / RCSB / EBI]
PDBsum 2I8W; -.
ModBase O09046.
PTM databases
PhosphoSite O09046; -.
Organism-specific databases
MGI MGI:109552; Il4i1.
Gene expression databases
CleanEx MM_IL4I1; -.
GermOnline ENSMUSG00000074141; Mus musculus.
Ontologies
GO
GO:0005764; Cellular component: lysosome (inferred from direct assay from MGI).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0001716; Molecular function: L-amino-acid oxidase activity (inferred from direct assay from MGI).
GO:0009072; Biological process: aromatic amino acid family metabolic process (inferred from direct assay from MGI).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000759; Adrndx_reductase.
IPR001613; Amineoxid_fl.
IPR002937; Amino_oxidase.
Graphical view of domain structure.
Pfam PF01593; Amino_oxidase; 1.
Pfam graphical view of domain structure.
PRINTS PR00419; ADXRDTASE.
PR00757; AMINEOXDASEF.
Proteomics databases
PRIDE O09046; -.
Genome annotation databases
Ensembl ENSMUSG00000074141; Mus musculus. [Contig view]
GeneID 14204; -.
KEGG mmu:14204; -.
Phylogenomic databases
HOVERGEN O09046; -.
Other
NextBio 285446; -.
SOURCE Il4i1; Mus musculus.
ProtoNet O09046.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative promoter usage; FAD; Flavoprotein; Glycoprotein; Lysosome; Oxidoreductase; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    21  21     Potential. 
CHAIN   22   630  609     L-amino-acid oxidase. PRO_0000001711
NP_BIND   114   115  2     FAD (By similarity). 
NP_BIND   488   491  4     FAD (By similarity). 
BINDING   88    88        FAD (By similarity). 
BINDING   96    96        FAD (By similarity). 
BINDING   115   115        Substrate (By similarity). 
BINDING   286   286        FAD; via amide nitrogen and carbonyl oxygen (By similarity). 
BINDING   395   395        Substrate (By similarity). 
BINDING   479   479        FAD (By similarity). 
CARBOHYD   53    53        N-linked (GlcNAc...) (Potential). 
CARBOHYD   133   133        N-linked (GlcNAc...) (Potential). 
CARBOHYD   219   219        N-linked (GlcNAc...) (Potential). 
DISULFID   35   198        By similarity. 
VAR_SEQ   1     5        MAGLA -> MGARRAPQRPPCT (in isoform 2). VSP_017174
CONFLICT   12    12        A -> V (in Ref. 2; AAO17038/AAO17039). 
CONFLICT   56    56        S -> L (in Ref. 2; AAO65453/AAS00457). 
CONFLICT   184   184        M -> V (in Ref. 3; BAE30174/BAE31293). 
CONFLICT   385   385        R -> Q (in Ref. 2; AAO23118 and 3; BAE21502/BAE29676/BAE30047/BAE30174/ BAE31293). 
CONFLICT   454   454        Q -> R (in Ref. 3; BAE21502). 
CONFLICT   537   537        E -> Q (in Ref. 3; BAE21502). 
CONFLICT   551   551        P -> L (in Ref. 2; AAO17038/AAO17039). 
CONFLICT   568   568        A -> M (in Ref. 2; AAO17038/AAO17039). 
CONFLICT   598   630        PSEHVQVHGEVIPEWHGHGGSGTPQMHRVGDHS -> LRSMYRCMGKSSLSGMVMGDLAPRKCTEWGTTPNRKEEVS TQLLSQPSSGQTDHLH (in Ref. 3). 
Sequence information
Length: 630 AA [This is the length of the unprocessed precursor] Molecular weight: 70191 Da [This is the MW of the unprocessed precursor] CRC64: A674C5D60D89A071 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAGLALRLVL AATLLGLAGS LDWKAASSLN PIEKCMEDHD YEQLLKVVTL GLNRTSKPQK 

        70         80         90        100        110        120 
VVVVGAGVAG LVAAKMLSDA GHKVTILEAD NRIGGRIFTF RDEKTGWIGE LGAMRMPSSH 

       130        140        150        160        170        180 
RILHKLCRTL GLNLTQFTQY DENTWTEVHN VKLRNYVVEK MPEKLGYNLN NRERGHSPED 

       190        200        210        220        230        240 
IYQMALNKAF KDLKALGCKK AMNKFNKHTL LEYLLEEGNL SRPAVQLLGD VMSEEGFFYL 

       250        260        270        280        290        300 
SFAEALRAHA CLSDRLRYSR IVGGWDLLPR ALLSSLSGAL LLNAPVVSIT QGRNDVRVHI 

       310        320        330        340        350        360 
ATSLHSEKTL TADVVLLTAS GPALQRITFS PPLTRKRQEA LRALHYVAAS KVFLSFRRPF 

       370        380        390        400        410        420 
WHEEHIEGGH SNTDRPSRLI FYPARGEGSL LLASYTWSDA AAPFAGLSTD QTLRLVLQDV 

       430        440        450        460        470        480 
AALHGPVVFR LWDGRGVVKR WAEDPHSQGG FVVQPPLYGR EAEDYDWSAP FGRIYFAGEH 

       490        500        510        520        530        540 
TALPHGWVET AVKSGLRAAV RINNNYGYGE VDPQMMEHAY AEANYLDQYP EGERPEEQQA 

       550        560        570        580        590        600 
REEVSPDEQE PSHKHLLVET SPEGQQHAFV EAIPELQGHV FVETVPQEKG HAHQNIYPSE 

       610        620        630 
HVQVHGEVIP EWHGHGGSGT PQMHRVGDHS 

O09046 in FASTA format

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