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UniProtKB/Swiss-Prot entry O07835

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IORA_PYRKO
Primary accession number O07835
Secondary accession number Q5JFI0
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on March 29, 2005 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 58)
Name and origin of the protein
Protein name Indolepyruvate oxidoreductase subunit iorA
Synonyms IOR
EC 1.2.7.8
Indolepyruvate ferredoxin oxidoreductase subunit alpha
Gene name
Name: iorA
OrderedLocusNames: TK0136
From
Pyrococcus kodakaraensis (Thermococcus kodakaraensis) [TaxID: 69014] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Thermococcus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=KOD1;
DOI=10.1007/s004380050436; PubMed=9180697 [NCBI, ExPASy, EBI, Israel, Japan]
Siddiqui M.A., Fujiwara S., Imanaka T.;
"Indolepyruvate ferredoxin oxidoreductase from Pyrococcus sp. KOD1 possesses a mosaic structure showing features of various oxidoreductases.";
Mol. Gen. Genet. 254:433-439(1997).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=KOD1;
DOI=10.1101/gr.3003105; PubMed=15710748 [NCBI, ExPASy, EBI, Israel, Japan]
Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
Genome Res. 15:352-363(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D86221; BAA20528.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP006878; BAD84325.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_182549.1; -.
3D structure databases
HSSP O28604; 1JNR. [HSSP ENTRY / PDB]
ModBase O07835.
Enzyme and pathway databases
BioCyc TKOD69014:TK0136-MON; -.
Ontologies
GO
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0043805; Molecular function: indolepyruvate ferredoxin oxidoreductase activity (inferred from electronic annotation from EC).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030976; Molecular function: thiamin pyrophosphate binding (inferred from electronic annotation from InterPro).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR017721; Indolepyruvate_Fd_OxRdtase_asu.
IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
IPR011766; TPP_enzyme_bd_C.
Graphical view of domain structure.
Pfam PF00037; Fer4; 1.
PF01855; POR_N; 1.
PF02775; TPP_enzyme_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PROSITE PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 2.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 3235682; -.
GenomeReviews AP006878_GR; TK0136.
KEGG tko:TK0136; -.
NMPDR fig|69014.3.peg.304; -.
Phylogenomic databases
HOGENOM O07835; -.
Genome annotation databases
CMR O07835; TK0136.
Other
ProtoNet O07835.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Repeat; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   647  647     Indolepyruvate oxidoreductase subunit iorA. PRO_0000099930
DOMAIN   585   614  30     4Fe-4S ferredoxin-type 1. 
DOMAIN   616   645  30     4Fe-4S ferredoxin-type 2. 
METAL   625   625        Iron-sulfur (4Fe-4S) (Potential). 
METAL   628   628        Iron-sulfur (4Fe-4S) (Potential). 
METAL   631   631        Iron-sulfur (4Fe-4S) (Potential). 
METAL   635   635        Iron-sulfur (4Fe-4S) (Potential). 
CONFLICT   26    26        A -> E (in Ref. 1; BAA20528). 
CONFLICT   50    54        DTMAA -> IRWQT (in Ref. 1; BAA20528). 
CONFLICT   311   311        P -> R (in Ref. 1; BAA20528). 
CONFLICT   602   603        NA -> KT (in Ref. 1; BAA20528). 
Sequence information
Length: 647 AA [This is the length of the unprocessed precursor] Molecular weight: 70900 Da [This is the MW of the unprocessed precursor] CRC64: AE24D283C96CDBF7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAKVTDIVLW DKPGERVLLL GNHAIARGAL EANIAVFAAY PGTPSSELTD TMAAVAKKAG 

        70         80         90        100        110        120 
VYMEYSTNEK VAFETALAAA WSGLRAMTAM KHVGLNVAAD SFLSSVGMGV EGGFVIMVAD 

       130        140        150        160        170        180 
DPSMWSSQNE QDTRVYAKFA NVPVLEPSSP HEAKEMTKYA FELSEKFKHF VILRTTTRSS 

       190        200        210        220        230        240 
HARGDVVLGE LPEEIKTGKR KFGKFKKDPT RFVDVPAHAR KFHPLILEKI EKIREELNNC 

       250        260        270        280        290        300 
PFNWIEGKED AKVGIIAPGL SYAYVKEALA WLGVEDVKIL KLGTPFPVPY GLLGKFFDGL 

       310        320        330        340        350        360 
EKVLIVEELE PVVEEQVKTW AYDKGLRIPI HGKDLVPRVY EMTTRRAVEA IAKFLGLETP 

       370        380        390        400        410        420 
INFAEIDEKY EKVSQIVPPR PPSLCPACPH RNSFFAIRKA AGPKAIYPSD IGCYTLGVLP 

       430        440        450        460        470        480 
PLRTVDTTVA MGASIGIGHG LSIAMNGSLA EEEHKEGKEK QIIVATIGDS TFYHTGLPAL 

       490        500        510        520        530        540 
ANAIYNRSNV LIVVLDNLVT AMTGDQPNPG TGQTPHGMGK RIPIEDVAKA MGADFVAVVD 

       550        560        570        580        590        600 
PYDIKATYET IKKALEVEGV SVVVSRQVCA LYKIGQMRRR GMKWPIYHVV EDKCTGCKIC 

       610        620        630        640 
INAYGCPAIY WDPETKKAKV DPTMCWGCGG CAQVCPFDAF EPMKEGE
O07835 in FASTA format

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