NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=GIR10;
PubMed=9534249 [NCBI, ExPASy, EBI, Israel, Japan]
Labo M., Gusberti L., de Rossi E., Speziale P., Riccardi G.;
"Determination of a 15437 bp nucleotide sequence around the inhA gene of Mycobacterium avium and similarity analysis of the products of putative ORFs.";
Microbiology 144:807-814(1998).

Comments

CATALYTIC ACTIVITY: Acyl-[acyl-carrier-protein] + NAD⁺ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH.
PATHWAY: Lipid metabolism; fatty acid biosynthesis .
SUBUNIT: Homotetramer (By similarity).
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF002133; AAC46204.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P46533; 1ENY. [HSSP ENTRY / PDB]

SMR

O07400; 2-268.

ModBase

O07400.

Ontologies

GO:0005488;	Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004318;	Molecular function: enoyl-[acyl-carrier-protein] reductase (NADH) activity (inferred from electronic annotation from InterPro).
GO:0006633;	Biological process: fatty acid biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002198; DHase_sc/Rdtase_SDR.
IPR014358; Enoyl-ACP_rdct.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.
PTHR19410:SF12; Enoyl-ACP_rdct; 1.

Other

ProtoNet

O07400.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Fatty acid biosynthesis; Lipid synthesis; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 268`	`268`	`Enoyl-[acyl-carrier-protein] reductase [NADH].`	`PRO_0000054914`
`NP_BIND`	`135 164`	`30`	`NAD (Potential).`
`BINDING`	`157 157`		`Substrate (By similarity).`

Sequence information

Length: 268 AA [This is the length of the unprocessed precursor]

Molecular weight: 28530 Da [This is the MW of the unprocessed precursor]

CRC64: F73501BD2B0F9990 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAGLLDGKRI LVTGIITDSS IAFHIAKVAQ EAGAQLVLTG FDRLRLIQRI VDRLPEKAPL 

        70         80         90        100        110        120 
IELDVQNEEH LNTLAQRVTG EIGEGNKLDG VVHSIASSET GMADQPFFDA PYEDVSKGIH 

       130        140        150        160        170        180 
ISADSDASLA KALLPIMNPG GSIVGMDFDP SRAMPAYNWM TVAKSALESV NRFVAREAGP 

       190        200        210        220        230        240 
HGVRSNLVAA GPIRTLAMAG IVGGVLGDQA AEQIRLLEEG WDQRAPIGWN MKDPTPVAKT 

       250        260 
VCALLSDWLP ATTGTIIYAD RGASTQLL

O07400 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools