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UniProtKB/Swiss-Prot entry O06913

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FRDA_HELPY
Primary accession number O06913
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1997 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 68)
Name and origin of the protein
Protein name Fumarate reductase flavoprotein subunit
Synonym EC 1.3.99.1
Gene name
Name: frdA
OrderedLocusNames: HP_0192
From
Helicobacter pylori (Campylobacter pylori) [TaxID: 210] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 43629 / JCM 7656 / NCTC 11639 / UA802;
DOI=10.1016/S0378-1119(97)00550-7; PubMed=9434188 [NCBI, ExPASy, EBI, Israel, Japan]
Ge Z., Jiang Q., Kalisiak M.S., Taylor D.E.;
"Cloning and functional characterization of Helicobacter pylori fumarate reductase operon comprising three structural genes coding for subunits C, A and B.";
Gene 204:227-234(1997).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700392 / 26695;
DOI=10.1038/41483; PubMed=9252185 [NCBI, ExPASy, EBI, Israel, Japan]
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
"The complete genome sequence of the gastric pathogen Helicobacter pylori.";
Nature 388:539-547(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U78101; AAC46064.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000511; AAD07259.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H64543; H64543.
RefSeq NP_206991.1; -.
3D structure databases
HSSP P17412; 1QLA. [HSSP ENTRY / PDB]
SMR O06913; 1-682.
ModBase O06913.
Protein-protein interaction databases
DIP DIP:3345N; -.
Ontologies
GO
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0000104; Molecular function: succinate dehydrogenase activity (inferred from electronic annotation from EC).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR003953; FAD_bind2_N.
IPR003952; FRD_SDH_FAD_BS.
IPR004112; Fum_Rdtase/Succ_DHase_flav_C.
IPR014006; Succ_Dhase_frdA_Gneg.
Graphical view of domain structure.
Pfam PF00890; FAD_binding_2; 1.
PF02910; Succ_DH_flav_C; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01812; sdhA_frdA_Gneg; 1.
PROSITE PS00504; FRD_SDH_FAD_BINDING; 1.
Genome annotation databases
GeneID 900116; -.
GenomeReviews AE000511_GR; HP_0192.
KEGG hpy:HP0192; -.
NMPDR fig|85962.1.peg.189; -.
TIGR HP_0192; -.
Phylogenomic databases
HOGENOM O06913; -.
Other
ProtoNet O06913.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Electron transport; FAD; Flavoprotein; Oxidoreductase; Transport.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   714  714     Fumarate reductase flavoprotein subunit. PRO_0000158662
NP_BIND   9    23  15     FAD (Potential). 
ACT_SITE   257   257        By similarity. 
ACT_SITE   273   273        By similarity. 
MOD_RES   43    43        Tele-8alpha-FAD histidine (By similarity). 
CONFLICT   112   112        K -> R (in Ref. 1; AAC46064). 
CONFLICT   170   175        HHKVDI -> NTTKWIL (in Ref. 1; AAC46064). 
CONFLICT   361   361        K -> E (in Ref. 1; AAC46064). 
CONFLICT   371   373        VPA -> MPT (in Ref. 1; AAC46064). 
CONFLICT   513   513        R -> K (in Ref. 1; AAC46064). 
CONFLICT   615   624        MEISPDFRGY -> WKSALILGAM (in Ref. 1; AAC46064). 
CONFLICT   658   658        I -> V (in Ref. 1; AAC46064). 
CONFLICT   699   699        E -> D (in Ref. 1; AAC46064). 
CONFLICT   703   703        Q -> K (in Ref. 1; AAC46064). 
Sequence information
Length: 714 AA [This is the length of the unprocessed precursor] Molecular weight: 80121 Da [This is the MW of the unprocessed precursor] CRC64: D4639213CB19B3A9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKITYCDALI IGGGLAGLRA SIACKQKGLN TIVLSLVPVR RSHSAAAQGG MQASLANAKK 

        70         80         90        100        110        120 
SEGDNEDLHF LDTVKGSDWG CDQQVARMFV TTAPKAIREL ASWGVPWTRI KKGDRPAVVN 

       130        140        150        160        170        180 
GEHVTITERD DRHGYILSRD FGGTKKWRTC FTADATGHTM LYAVANEALH HKVDIQDRKD 

       190        200        210        220        230        240 
MLAFIHHDNK CYGAVVRDLI TGEISAYVSK GTLLATGGYG RVYKHTTNAV ICDGAGAASA 

       250        260        270        280        290        300 
LETGVAKLGN MEAVQFHPTA LVPSGILMTE GCRGDGGVLR DKFGRRFMPA YEPEKKELAS 

       310        320        330        340        350        360 
RDVVSRRILE HIQKGYGAKS PYGDHVWLDI AILGRNHVEK NLRDVRDIAM TFAGIDPADS 

       370        380        390        400        410        420 
KEQTKDNMQG VPANEPEYGQ AMAKQKGWIP IKPMQHYSMG GVRTNPKGET HLKGLFCAGE 

       430        440        450        460        470        480 
AACWDLHGFN RLGGNSVSEA VVAGMIIGDY FASHCLEAQI EINTQKVEAF IKESQDYMHF 

       490        500        510        520        530        540 
LLHNEGKEDV YEIRERMKEV MDEKVGVFRE GKRLEEALKE LQELYARSKN ICVKNKVLHN 

       550        560        570        580        590        600 
NPELEDAYRT KKMLKLALCI TQGALLRTES RGAHTRIDYP KRDDEKWLNR TLASWPSAEQ 

       610        620        630        640        650        660 
DMPTIEYEEL DVMKMEISPD FRGYGKKGNF IPHPKKEERD AEILKTILEL EKLGKDRIEV 

       670        680        690        700        710 
QHALMPFELQ EKYKARNMRL EDEEVRARGE HLYSFNVHEL LDQHNANLKG EHHE
O06913 in FASTA format

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