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UniProtKB/Swiss-Prot entry O05940

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DLDH_RHIET
Primary accession number O05940
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on July 1, 1997 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 60)
Name and origin of the protein
Protein name Probable dihydrolipoyl dehydrogenase [Fragment]
Synonyms EC 1.8.1.4
Dihydrolipoamide dehydrogenase
E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes
ORF-E3
Gene name None
From
Rhizobium etli [TaxID: 29449] 
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=CE3;
DOI=10.1016/S0378-1097(97)00069-4; PubMed=9141657 [NCBI, ExPASy, EBI, Israel, Japan]
Tate R., Riccio A., Iaccarino M., Patriarca E.J.;
"Cloning and transcriptional analysis of the lipA (lipoic acid synthetase) gene from Rhizobium etli.";
FEMS Microbiol. Lett. 149:165-172(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y11708; CAA72399.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P31023; 1DXL. [HSSP ENTRY / PDB]
ModBase O05940.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0004148; Molecular function: dihydrolipoyl dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0045454; Biological process: cell redox homeostasis (inferred from electronic annotation from InterPro).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR006258; Lipoamide_DHase.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
IPR012999; Pyr_OxRdtase_I_AS.
IPR001327; Pyr_OxRdtase_NAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:3.30.390.30; Pyr_redox_dim; 1.
PANTHER PTHR22912:SF20; Lipoamide_DH; 1.
Pfam PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
PF02852; Pyr_redox_dim; 1.
Pfam graphical view of domain structure.
PRINTS PR00411; PNDRDTASEI.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00076; PYRIDINE_REDOX_1; PARTIAL.
Other
ProtoNet O05940.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; FAD; Flavoprotein; Glycolysis; NAD; Oxidoreductase; Redox-active center.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   <1   277  >277     Probable dihydrolipoyl dehydrogenase. PRO_0000068041
NP_BIND   83    86  4     NAD (By similarity). 
ACT_SITE   259   259        Proton acceptor (By similarity). 
BINDING   17    17        NAD (By similarity). 
BINDING   51    51        NAD; via amide nitrogen (By similarity). 
BINDING   125   125        FAD (By similarity). 
BINDING   133   133        FAD; via amide nitrogen (By similarity). 
NON_TER   1     1         
Sequence information
Length: 277 AA [This is the length of the partial sequence of the unprocessed precursor] Molecular weight: 29547 Da [This is the MW of the partial sequence of the unprocessed precursor] CRC64: CD3E3B5DB1FE4C4F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
EFASFYRSMG VDVTVVEVMP TIMPVEDAEI TAIARKQLEK RGLKIFTSAK VTKVEKGAGS 

        70         80         90        100        110        120 
ITAHVETSDG KVQQITADRM ISAVGVQGNI ENLGLEALGV LTDRRWLVAD GYGKTNVAGI 

       130        140        150        160        170        180 
YAIGDVAGPP IVAHKAEHEG VVCVEKIAGV PNVHPTDKGK VPGCTYCNPQ VASVGLTEAK 

       190        200        210        220        230        240 
AKELGSDIRV GRFSFAANRK AIALGEDQGM VKVIFDKKTG ELLGAHMVGA EVTELIQGFV 

       250        260        270 
VAMNLETTEE ELMHTIFPHP TVSETMKEAV LDAYGRV
O05940 in FASTA format

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