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UniProtKB/Swiss-Prot entry O04420


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name URIC_ARATH
Primary accession number O04420
Secondary accession numbers O64848 Q94A71
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on February 5, 2008 (Sequence version 2)
Annotations were last modified on    December 16, 2008 (Entry version 61)
Name and origin of the protein
Protein name Uricase
Synonyms EC 1.7.3.3
Urate oxidase
Nodulin 35 homolog
Gene name
OrderedLocusNames: At2g26230
ORFNames: T1D16.13
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Landsberg erecta;
Marchfelder A., Binder S., Brennicke A.;
"A nodulin-35 homologue is encoded in the Arabidopsis genome.";
Trends Plant Sci. 2:167-168(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1038/45471; PubMed=10617197 [NCBI, ExPASy, EBI, Israel, Japan]
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
Nature 402:761-768(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y11120; CAA72005.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC004484; AAC14527.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY050318; AAK91335.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY101530; AAM26651.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY087805; AAM65341.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H84657; H84657.
RefSeq NP_180191.1; -.
UniGene At.5406
3D structure databases
HSSP Q00511; 1UOX. [HSSP ENTRY / PDB]
ModBase O04420.
Organism-specific databases
TAIR At2g26230; -.
Gene expression databases
ArrayExpress O04420; -.
Ontologies
GO
GO:0005777; Cellular component: peroxisome (inferred from electronic annotation from UniProtKB-KW).
GO:0004846; Molecular function: urate oxidase activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006144; Biological process: purine base metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR002042; Uricase.
Graphical view of domain structure.
Gene3D G3DSA:3.10.270.10; Uricase; 1.
PANTHER PTHR10395:SF1; Uricase; 1.
Pfam PF01014; Uricase; 2.
Pfam graphical view of domain structure.
PRINTS PR00093; URICASE.
ProDom PD003367; Uricase; 2.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR03383; urate_oxi; 1.
PROSITE PS00366; URICASE; 1.
Proteomics databases
PRIDE O04420; -.
Proteomic databases
ProMEX O04420; -.
Genome annotation databases
GeneID 817163; -.
GenomeReviews CT485783_GR; AT2G26230.
KEGG ath:AT2G26230; -.
Other
ProtoNet O04420.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Oxidoreductase; Peroxisome; Purine metabolism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   309  309     Uricase. PRO_0000165999
MOTIF   307   309  3     Microbody targeting signal (Potential). 
ACT_SITE   182   182        Charge relay system (By similarity). 
ACT_SITE   238   238        Charge relay system (By similarity). 
CONFLICT   11    11        D -> E (in Ref. 1; CAA72005). 
Sequence information
Length: 309 AA [This is the length of the unprocessed precursor] Molecular weight: 34881 Da [This is the MW of the unprocessed precursor] CRC64: 9DB8FAD58FDF1404 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAQEADGIRL DQRHGKARVR VGRVWRHAHD GSHHFVEWNV SISLLSHCLS SYRLDDNSDI 

        70         80         90        100        110        120 
VATDTIKNTV YVKAKECGDR LSVEEFAILI GKHFCSFYPQ VFTAIVNIIE KPWERVSIDG 

       130        140        150        160        170        180 
KPHLHGFKLG SENHTTEARV EKSGALNLTS GIGGLALLKT TQSGFERFVR DKYTILPETR 

       190        200        210        220        230        240 
ERMLATEVNA SWRYSYESVA SIPTKGLYFS EKFMDVKKVL MDTFFGPPET GVYSPSVQRT 

       250        260        270        280        290        300 
LYLMGSAVLK RFADVSSIHL KMPNIHFLPV NLSTKENPSM VKFKDDVYLP TDEPHGSIEA 


TLSRITSKL 

O04420 in FASTA format

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View entry in raw text format (no links)
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