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UniProtKB/Swiss-Prot entry O02640

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDHM_CAEEL
Primary accession number O02640
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on July 1, 1997 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 65)
Name and origin of the protein
Protein name Probable malate dehydrogenase, mitochondrial [Precursor]
Synonym EC 1.1.1.37
Gene name
Name: mdh-1
ORFNames: F20H11.3
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF002197; AAB53985.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C88486; C88486.
RefSeq NP_498457.1; -.
UniGene Cel.5076
3D structure databases
HSSP P00346; 1MLD. [HSSP ENTRY / PDB]
ModBase O02640.
Organism-specific databases
WormBase WBGene00003162; mdh-1.
WormPep F20H11.3; CE09512. [WormPep / WorfDB]
Gene expression databases
ArrayExpress O02640; -.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0009792; Biological process: embryonic development ending in birth or egg hatching (inferred from mutant phenotype from WormBase).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from InterPro).
GO:0006108; Biological process: malate metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0040010; Biological process: positive regulation of growth rate (inferred from mutant phenotype from WormBase).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR010097; Malate_DHase_NAD-dep_euk_g_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11540:SF1; MDH_euk_g_bac; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
TIGRFAMs TIGR01772; MDH_euk_gproteo; 1.
PROSITE PS00068; MDH; 1.
Genome annotation databases
Ensembl F20H11.3; Caenorhabditis elegans. [Contig view]
GeneID 175936; -.
KEGG cel:F20H11.3; -.
Other
NextBio 890380; -.
ProtoNet O02640.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Mitochondrion; NAD; Oxidoreductase; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion. 
CHAIN   ?   341        Probable malate dehydrogenase, mitochondrial. PRO_0000018632
NP_BIND   35    41  7     NAD (By similarity). 
NP_BIND   144   146  3     NAD (By similarity). 
ACT_SITE   204   204        Proton acceptor (By similarity). 
BINDING   61    61        NAD (By similarity). 
BINDING   108   108        Substrate (By similarity). 
BINDING   114   114        Substrate (By similarity). 
BINDING   121   121        NAD (By similarity). 
BINDING   146   146        Substrate (By similarity). 
BINDING   180   180        Substrate (By similarity). 
BINDING   255   255        NAD (By similarity). 
Sequence information
Length: 341 AA [This is the length of the unprocessed precursor] Molecular weight: 35120 Da [This is the MW of the unprocessed precursor] CRC64: 7515F9C1727AEFB5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSLPAKTLVQ AAANSGLRAV SVRHSSQAPK VALLGAAGGI GQPLGLLLKQ DPLVAHLALY 

        70         80         90        100        110        120 
DVVNTPGVAA DLSHIDSNAK VTAHTGPKEL YAAVENADVI VIPAGVPRKP GMTRDDLFNT 

       130        140        150        160        170        180 
NAGIVRDLAA VIAKASPKAL IAIITNPVNS TVPIASEVLK KAGVYDPKRV FGVTTLDVVR 

       190        200        210        220        230        240 
SQAFVSELKG HDASKTVVPV VGGHAGITII PLLSQVKPST KFSEEEISKL TPRIQDAGTE 

       250        260        270        280        290        300 
VVNAKAGAGS ATLSMALAGA RFANALVRGI KGEKNVQCAY VASDAVKGVE YFSTPVELGP 

       310        320        330        340 
NGVEKILGVG KVSAYEQKLI DASVPELNKN IAKGVAFVKG N
O02640 in FASTA format

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