UniProtKB/Swiss-Prot entry Q91ZX7

• FUNCTION: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
• SUBUNIT: Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa amino-terminal subunit. Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Interacts with LRPAP1 (By similarity). Intracellular domain interacts with MAFB.
• INTERACTION:
  P97318:Dab1; NbExp=1; IntAct=EBI-300955, EBI-81680;
  Q62108:Dlg4; NbExp=1; IntAct=EBI-300955, EBI-300895;
  Q9WVI9:Mapk8ip1; NbExp=1; IntAct=EBI-300955, EBI-74515;
  Q9ERE9:Mapk8ip2; NbExp=1; IntAct=EBI-300955, EBI-74576;
  Q9D6K5:Synj2bp; NbExp=1; IntAct=EBI-300955, EBI-300910;
  
• SUBCELLULAR LOCATION: Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane; Single-pass type I membrane protein (By similarity). Membrane, coated pit (By similarity).
• SUBCELLULAR LOCATION: Low-density lipoprotein receptor-related protein 1 515 kDa subunit: Cell membrane; Peripheral membrane protein; Extracellular side (By similarity). Membrane, coated pit (By similarity).
• SUBCELLULAR LOCATION: Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm (By similarity). Nucleus (By similarity). Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus (By similarity).
• PTM: Phosphorylated on serine and threonine residues (By similarity).
• PTM: Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1 (By similarity).
• PTM: Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane (By similarity).
• MISCELLANEOUS: Mice lacking Lrp1 die during early embryogenesis around 14 dpc.
• SIMILARITY: Belongs to the LDLR family.
• SIMILARITY: Contains 22 EGF-like domains.
• SIMILARITY: Contains 31 LDL-receptor class A domains.
• SIMILARITY: Contains 34 LDL-receptor class B repeats.