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UniProtKB/Swiss-Prot entry Q9UBT3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DKK4_HUMAN
Primary accession number Q9UBT3
Secondary accession numbers Q3KNX0 Q9Y4C3
Integrated into Swiss-Prot on February 21, 2001
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 64)
Name and origin of the protein
Protein name Dickkopf-related protein 4 [Precursor]
Synonyms Dickkopf-4
Dkk-4
hDkk-4
Contains Dickkopf-related protein 4 short form
Gene name
Name: DKK4
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-28 AND 134-144, AND PROTEOLYTIC PROCESSING.
DOI=10.1016/S0378-1119(99)00365-0; PubMed=10570958 [NCBI, ExPASy, EBI, Israel, Japan]
Krupnik V.E., Sharp J.D., Jiang C., Robison K., Chickering T.W., Amaravadi L., Brown D.E., Guyot D., Mays G., Leiby K., Chang B., Duong T., Goodearl A.D.J., Gearing D.P., Sokol S.Y., McCarthy S.A.;
"Functional and structural diversity of the human Dickkopf gene family.";
Gene 238:301-313(1999).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tate G., Mitsuya T.;
"Human Dickkopf as well as DAN family members, Cerberus and Gremlin, are preferentially expressed in the epithelial malignant cell lines.";
J. Biochem. Mol. Biol. Biophys. 3:239-242(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PROTEIN SEQUENCE OF 19-33.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF177397; AAF02677.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB018005; BAA33475.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB017788; BAA33438.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC107046; AAI07047.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC107047; AAI07048.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_055235.1; -.
UniGene Hs.159311
3D structure databases
HSSP P25687; 1IMT. [HSSP ENTRY / PDB]
ModBase Q9UBT3.
Organism-specific databases
GeneCards GC08M042350; -.
H-InvDB HIX0034234; -.
HGNC HGNC:2894; DKK4.
GenAtlas DKK4.
MIM 605417; gene. [NCBI / EBI]
PharmGKB PA27348; -.
GeneCards Q9UBT3.
Gene expression databases
ArrayExpress Q9UBT3; -.
CleanEx HS_DKK4; -.
GermOnline ENSG00000104371; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from InterPro).
GO:0007275; Biological process: multicellular organismal development (inferred from electronic annotation from InterPro).
GO:0030178; Biological process: negative regulation of Wnt receptor signaling pathway (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR006796; Dickkopf_N.
Graphical view of domain structure.
Pfam PF04706; Dickkopf_N; 1.
Pfam graphical view of domain structure.
Proteomics databases
PRIDE Q9UBT3; -.
Genome annotation databases
Ensembl ENSG00000104371; Homo sapiens. [Contig view]
GeneID 27121; -.
KEGG hsa:27121; -.
Phylogenomic databases
HOGENOM Q9UBT3; -.
HOVERGEN Q9UBT3; -.
Other
NextBio 49808; -.
SOURCE DKK4; Homo sapiens.
ProtoNet Q9UBT3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cleavage on pair of basic residues; Developmental protein; Direct protein sequencing; Secreted; Signal; Wnt signaling pathway.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    18  18      
CHAIN   19   224  206     Dickkopf-related protein 4. PRO_0000007225
CHAIN   134   224  91     Dickkopf-related protein 4 short form. PRO_0000007226
REGION   41    90  50     DKK-type Cys-1. 
REGION   145   218  74     DKK-type Cys-2. 
CONFLICT   93    93        M -> L (in Ref. 2; BAA33438). 
Sequence information
Length: 224 AA [This is the length of the unprocessed precursor] Molecular weight: 24876 Da [This is the MW of the unprocessed precursor] CRC64: 45F8EBC476961357 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVAAVLLGLS WLCSPLGALV LDFNNIRSSA DLHGARKGSQ CLSDTDCNTR KFCLQPRDEK 

        70         80         90        100        110        120 
PFCATCRGLR RRCQRDAMCC PGTLCVNDVC TTMEDATPIL ERQLDEQDGT HAEGTTGHPV 

       130        140        150        160        170        180 
QENQPKRKPS IKKSQGRKGQ EGESCLRTFD CGPGLCCARH FWTKICKPVL LEGQVCSRRG 

       190        200        210        220 
HKDTAQAPEI FQRCDCGPGL LCRSQLTSNR QHARLRVCQK IEKL 

Q9UBT3 in FASTA format

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