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UniProtKB/Swiss-Prot entry O94907


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DKK1_HUMAN
Primary accession number O94907
Secondary accession numbers None
Integrated into Swiss-Prot on February 21, 2001
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 69)
Name and origin of the protein
Protein name Dickkopf-related protein 1 [Precursor]
Synonyms Dickkopf-1
Dkk-1
hDkk-1
SK
Gene name
Name: DKK1
ORFNames: UNQ492/PRO1008
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Leiomyosarcoma;
DOI=10.1074/jbc.274.27.19465; PubMed=10383463 [NCBI, ExPASy, EBI, Israel, Japan]
Fedi P., Bafico A., Nieto Soria A., Burgess W.H., Miki T., Bottaro D.P., Kraus M.H., Aaronson S.A.;
"Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling.";
J. Biol. Chem. 274:19465-19472(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Fetal kidney;
DOI=10.1016/S0378-1119(99)00365-0; PubMed=10570958 [NCBI, ExPASy, EBI, Israel, Japan]
Krupnik V.E., Sharp J.D., Jiang C., Robison K., Chickering T.W., Amaravadi L., Brown D.E., Guyot D., Mays G., Leiby K., Chang B., Duong T., Goodearl A.D.J., Gearing D.P., Sokol S.Y., McCarthy S.A.;
"Functional and structural diversity of the human Dickkopf gene family.";
Gene 238:301-313(1999).
[3]
NUCLEOTIDE SEQUENCE.
Tate G., Suzuki T., Mitsuya T.;
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10965128 [NCBI, ExPASy, EBI, Israel, Japan]
Roessler E., Du Y., Glinka A., Dutra A., Niehrs C., Muenke M.;
"The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly.";
Cytogenet. Cell Genet. 89:220-224(2000).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
PROTEIN SEQUENCE OF 32-46.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF127563; AAD21087.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF177394; AAF02674.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB020315; BAA34651.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF261158; AAG15544.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF261157; AAG15544.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY359005; AAQ89364.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC001539; AAH01539.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_036374.1; -.
UniGene Hs.40499
3D structure databases
HSSP P25687; 1IMT. [HSSP ENTRY / PDB]
ModBase O94907.
Protein-protein interaction databases
IntAct O94907; 2.
Organism-specific databases
GeneCards GC10P053744; -.
H-InvDB HIX0008834; -.
HGNC HGNC:2891; DKK1.
GenAtlas DKK1.
HPA CAB009726; -.
MIM 605189; gene. [NCBI / EBI]
PharmGKB PA27345; -.
GeneCards O94907.
Gene expression databases
ArrayExpress O94907; -.
CleanEx HS_DKK1; -.
GermOnline ENSG00000107984; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from InterPro).
GO:0005886; Cellular component: plasma membrane (inferred from direct assay from MGI).
GO:0008083; Molecular function: growth factor activity (traceable author statement from ProtInc).
GO:0050750; Molecular function: low-density lipoprotein receptor binding (inferred from direct assay from MGI).
GO:0004871; Molecular function: signal transducer activity (traceable author statement from ProtInc).
GO:0030178; Biological process: negative regulation of Wnt receptor signaling pathway (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR006796; Dickkopf_N.
Graphical view of domain structure.
Pfam PF04706; Dickkopf_N; 1.
Pfam graphical view of domain structure.
Proteomics databases
PRIDE O94907; -.
Genome annotation databases
Ensembl ENSG00000107984; Homo sapiens. [Contig view]
GeneID 22943; -.
KEGG hsa:22943; -.
Phylogenomic databases
HOGENOM O94907; -.
HOVERGEN O94907; -.
Other
NextBio 43697; -.
SOURCE DKK1; Homo sapiens.
ProtoNet O94907.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Developmental protein; Direct protein sequencing; Glycoprotein; Secreted; Signal; Wnt signaling pathway.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    31  31      
CHAIN   32   266  235     Dickkopf-related protein 1. PRO_0000007218
REGION   85   138  54     DKK-type Cys-1. 
REGION   189   263  75     DKK-type Cys-2. 
CARBOHYD   256   256        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 266 AA [This is the length of the unprocessed precursor] Molecular weight: 28672 Da [This is the MW of the unprocessed precursor] CRC64: 5E878B2CCE4236BA [This is a checksum on the sequence]
        10         20         30         40         50         60 
MMALGAAGAT RVFVAMVAAA LGGHPLLGVS ATLNSVLNSN AIKNLPPPLG GAAGHPGSAV 

        70         80         90        100        110        120 
SAAPGILYPG GNKYQTIDNY QPYPCAEDEE CGTDEYCASP TRGGDAGVQI CLACRKRRKR 

       130        140        150        160        170        180 
CMRHAMCCPG NYCKNGICVS SDQNHFRGEI EETITESFGN DHSTLDGYSR RTTLSSKMYH 

       190        200        210        220        230        240 
TKGQEGSVCL RSSDCASGLC CARHFWSKIC KPVLKEGQVC TKHRRKGSHG LEIFQRCYCG 

       250        260 
EGLSCRIQKD HHQASNSSRL HTCQRH 

O94907 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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