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UniProtKB/Swiss-Prot entry B0RIP4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU3_CLAMS
Primary accession number B0RIP4
Secondary accession numbers None
Integrated into Swiss-Prot on May 20, 2008
Sequence was last modified on April 8, 2008 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 7)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase
IMDH
3-IPM-DH
Gene name
Name: leuB
OrderedLocusNames: CMS1424
From
Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / JCM 9667) [TaxID: 31964] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Micrococcineae; Microbacteriaceae; Clavibacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.01598-07; PubMed=18192393 [NCBI, ExPASy, EBI, Israel, Japan]
Bentley S.D., Corton C., Brown S.E., Barron A., Clark L., Doggett J., Harris B., Ormond D., Quail M.A., May G., Francis D., Knudson D., Parkhill J., Ishimaru C.A.;
"Genome of the actinomycete plant pathogen Clavibacter michiganensis subsp. sepedonicus suggests recent niche adaptation.";
J. Bacteriol. 190:2150-2160(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AM849034; CAQ01535.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001710151.1; -.
3D structure databases
ModBase B0RIP4.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01035; -; 1.
PBIL [Tree]
InterPro IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
PROSITE PS00470; IDH_IMDH; 1.
Genome annotation databases
GeneID 6157256; -.
GenomeReviews AM849034_GR; CMS1424.
KEGG cms:CMS_1424; -.
CMR B0RIP4; CMS1424.
Other
ProtoNet B0RIP4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   355  355     3-isopropylmalate dehydrogenase. PRO_1000084277
NP_BIND   283   295  13     NAD (By similarity). 
METAL   223   223        Magnesium or manganese (By similarity). 
METAL   247   247        Magnesium or manganese (By similarity). 
METAL   251   251        Magnesium or manganese (By similarity). 
BINDING   98    98        Substrate (By similarity). 
BINDING   108   108        Substrate (By similarity). 
BINDING   132   132        Substrate (By similarity). 
BINDING   223   223        Substrate (By similarity). 
SITE   139   139  1     Important for catalysis (By similarity). 
SITE   190   190  1     Important for catalysis (By similarity). 
Sequence information
Length: 355 AA [This is the length of the unprocessed precursor] Molecular weight: 37195 Da [This is the MW of the unprocessed precursor] CRC64: 7D22C084DF79E199 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPRTISLAVV PGDGIGPEVV HEALRVLREA VPADVSLDTT QYPFGAGHFL ETGQILTDSD 

        70         80         90        100        110        120 
LAALAQHDAI LLGAVGGDPR DARLAGGIIE RGLLLKLRFA FDHYINLRPT ALLPGVASPL 

       130        140        150        160        170        180 
AAPGQVDFVV VREGTEGPYA GNGGVLRRGT EHEIATEVSV NTAHGVERTV RFAFELAEKR 

       190        200        210        220        230        240 
DRKRVTLVHK TNVLTFAGSL WQRTVDRVAA EHPDVTVDYL HVDATMIFLV TDPSRFDVIV 

       250        260        270        280        290        300 
SDNLFGDIIT DLAAAISGGI GLAASGNVNP TGAFPSMFEP VHGSAPDIAG QQKADPTAAI 

       310        320        330        340        350 
LSVALLLDHL GLSEAAARVS AAVSDDLAAR ATGDAAPRST AEVGDAILRA LSTNH
B0RIP4 in FASTA format

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