FUNCTION: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity).
CATALYTIC ACTIVITY: ATP + acetyl-CoA + HCO₃^- = ADP + phosphate + malonyl-CoA.
PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1 .
SUBUNIT: Acetyl-CoA carboxylase is an heterohexamer composed of biotin carboxyl carrier protein (accB), biotin carboxylase (accC) and two subunits each of ACCase subunit alpha (accA) and ACCase subunit beta (accD) (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the accA family.

Copyright

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Cross-references

Sequence databases

EMBL

CP000911; ABY38886.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001628456.1; -.

3D structure databases

ModBase

B0CJD4.

Ontologies

GO:0009317;	Cellular component: acetyl-CoA carboxylase complex (inferred from electronic annotation from InterPro).
GO:0003989;	Molecular function: acetyl-CoA carboxylase activity (inferred from electronic annotation from HAMAP).
GO:0006633;	Biological process: fatty acid biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00823; -; 1.
PBIL [Tree]

InterPro

IPR001095; Acetyl_CoA_COase_a_su.
IPR011763; COA_CT_C.
Graphical view of domain structure.

PANTHER

PTHR22855:SF3; Ac-CoA_carboxylA; 1.

PRINTS

PR01069; ACCCTRFRASEA.

TIGRFAMs

TIGR00513; accA; 1.

PROSITE

PS50989; COA_CT_CTER; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

GeneID

5837377; -.

GenomeReviews

CP000911_GR; BSUIS_A1873.

KEGG

bmt:BSUIS_A1873; -.

CMR

B0CJD4; BSUIS_A1873.

Other

ProtoNet

B0CJD4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; Fatty acid biosynthesis; Ligase; Lipid synthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 317`	`317`		`Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha.`	`PRO_1000083921`

Sequence information

Length: 317 AA [This is the length of the unprocessed precursor]

Molecular weight: 35013 Da [This is the MW of the unprocessed precursor]

CRC64: 28D0B15DD22C6786 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MYNYLDFEKP VADLEGQILE LKKLAQEQGS VEMGDEISRL EKRSADALKD IYRKLTPWQK 

        70         80         90        100        110        120 
AQIARHPDRP HCLEYIDRLF TEFTPLAGDR KFANDEALQA GFGRFNGTPV AIIGQEKGSD 

       130        140        150        160        170        180 
TKTRLKHNFG SARPEGYRKA VRIMEMADRF QLPLITFVDT AGAYPGVSAE ERGQAEAIAR 

       190        200        210        220        230        240 
STAECLKLRV PVISIIIGEG GSGGAIAIAV ANRVYMLEHS IYSVISPEGA ASILWHDSTR 

       250        260        270        280        290        300 
AKDAASNMRI TAQDLFDLKI IDGIIPEPLG GAHRGKESVI DATGDIIAAS LRSMKDIDGE 

       310 
TLKQERRQKF LEIGRNI

B0CJD4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools