[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Eye; NIH - Zebrafish Gene Collection (ZGC) project; Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).
CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol.
COFACTOR: Binds 1 2Fe-2S cluster (By similarity).
COFACTOR: Binds 1 3Fe-4S cluster (By similarity).
COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b composed of sdhc and sdhd (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
SIMILARITY: Contains 1 2Fe-2S ferredoxin-type domain.
SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC142799; AAI42800.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001092210.1; -.

UniGene

Dr.75182

3D structure databases

ModBase

A5PL98.

Organism-specific databases

ZFIN

ZDB-GENE-030131-8005; sdhb.

Ontologies

GO:0005743;	Cellular component: mitochondrial inner membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0051537;	Molecular function: 2 iron, 2 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051538;	Molecular function: 3 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051539;	Molecular function: 4 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009055;	Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008177;	Molecular function: succinate dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
GO:0022900;	Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810;	Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
GO:0006099;	Biological process: tricarboxylic acid cycle (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR006058; 2Fe2S_fd_BS.
IPR001450; 4Fe4S_Fe_S_bd.
IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.

Pfam

PF00111; Fer2; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00384; dhsB; 1.

PROSITE

PS00197; 2FE2S_FER_1; 1.
PS51085; 2FE2S_FER_2; 1.
PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

GeneID

562149; -.

KEGG

dre:562149; -.

Other

ProtoNet

A5PL98.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

2Fe-2S; 3Fe-4S; 4Fe-4S; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Transit peptide; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 25`	`25`	`Mitochondrion (By similarity).`
`CHAIN`	`26 280`	`255`	`Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial.`	`PRO_0000343801`
`DOMAIN`	`39 129`	`91`	`2Fe-2S ferredoxin-type.`
`DOMAIN`	`175 205`	`31`	`4Fe-4S ferredoxin-type.`
`METAL`	`92 92`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`97 97`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`100 100`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`112 112`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`185 185`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`188 188`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`191 191`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`195 195`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`242 242`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`248 248`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`252 252`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`BINDING`	`200 200`		`Ubiquinone; shared with dhsd (By similarity).`

Sequence information

Length: 280 AA [This is the length of the unprocessed precursor]

Molecular weight: 31740 Da [This is the MW of the unprocessed precursor]

CRC64: A16A68A72849B844 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAAVCFSLSR CCSAVHRPAV TAVRFAQTAA APAAQPRIKK FQIYRWDPDT VGDKPRMQTY 

        70         80         90        100        110        120 
EIDLNTCGPM VLDALIKIKN EMDSTLTFRR SCREGICGSC AMNINGGNTL ACLNKIDTNT 

       130        140        150        160        170        180 
SKVTKIYPLP HMYVVKDLVP DMSNFYAQYK SIEPYLKKKD ESQQGKQQYL QSVEDRQKLD 

       190        200        210        220        230        240 
GLYECILCAC CSTSCPSYWW NADKYLGPAV LMQAYRWMID SRDDFTEDRL SKLQDPFSLY 

       250        260        270        280 
RCHTIMNCTR TCPKGLNPGK AIAEIKKMMV TYKQKDAVAA

A5PL98 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools