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UniProtKB/Swiss-Prot entry A4XID4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AROE_CALS8
Primary accession number A4XID4
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on May 29, 2007 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 15)
Name and origin of the protein
Protein name Shikimate dehydrogenase
Synonym EC 1.1.1.25
Gene name
Name: aroE
OrderedLocusNames: Csac_1055
From
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903) [TaxID: 351627] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales; Thermoanaerobacterales Family III. Incertae Sedis; Caldicellulosiruptor.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., van de Werken H.J.G., Verhaart M.R.A., VanFossen A.L., Lewis D.L., Nichols J.D., Goorissen H.P., van Niel E.W.J., Stams F.J.M., Willquist K.U., Ward D.E., van der Oost J., Kelly R.M., Kengen S.M.W., Richardson P.;
"Genome sequence of the thermophilic hydrogen-producing bacterium Caldicellulosiruptor saccharolyticus DSM 8903.";
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000679; ABP66669.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001179860.1; -.
3D structure databases
ModBase A4XID4.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0004764; Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073; Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00222; -; 1.
PBIL [Tree]
InterPro IPR016040; NAD(P)-bd.
IPR011342; Quinate/shikimate_5-DHase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00507; aroE; 1.
Genome annotation databases
GeneID 5088559; -.
GenomeReviews CP000679_GR; Csac_1055.
KEGG csc:Csac_1055; -.
CMR A4XID4; Csac_1055.
Other
ProtoNet A4XID4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   279  279     Shikimate dehydrogenase. PRO_1000021269
NP_BIND   127   131  5     NADP (By similarity). 
ACT_SITE   67    67        Proton acceptor (Potential). 
Sequence information
Length: 279 AA [This is the length of the unprocessed precursor] Molecular weight: 31990 Da [This is the MW of the unprocessed precursor] CRC64: 2473596A74A01B29 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKKLYLIGKS LKHSISPLIH NKILSNFGID AVYSNVELPD FEKLKEFVEM VKKDGDVVGF 

        70         80         90        100        110        120 
NITIPYKEDI LEFCDEVSED VRIIQAANTV KKEGEKLVAY NTDWLGFKRS LEEVGISVKD 

       130        140        150        160        170        180 
KRILILGAGG AAKACIYGLY RMGVKEVFVA NRTYEKAESL KEVFQDILKI LPVEWLRRYE 

       190        200        210        220        230        240 
FKYDIIINTT SVGMFPNIES SPFDFENYVA GIPVFVYDMI YNPPKTTFLE EAEKKGSKTE 

       250        260        270 
NGLKMLVYQA VEAEKIWFDI VNLSQSFLLE ILKECEKKI 

A4XID4 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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