FUNCTION: Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ (By similarity).
CATALYTIC ACTIVITY: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O₂ = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H₂O₂ + 2 H₂O.
PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis .
SIMILARITY: Belongs to the pqqC family.

Copyright

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Cross-references

Sequence databases

EMBL

CP000577; ABN77550.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001044322.1; -.

3D structure databases

ModBase

A3PMI4.

Ontologies

GO:0033732;	Molecular function: pyrroloquinoline-quinone synthase activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0018189;	Biological process: pyrroloquinoline quinone biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00654; -; 1.
PBIL [Tree]

InterPro

IPR016084; Haem_Oase-like_multi-hlx.
IPR011845; PQQ_synth_PqqC.
IPR004305; TENA/THI4/PQQ_synth_PqqC.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.910.10; Haem_Oase-like_multi-hlx; 1.

Pfam

PF03070; TENA_THI-4; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02111; PQQ_syn_pqqC; 1.

ProtoNet

A3PMI4.

Genome annotation databases

GeneID

4897720; -.

GenomeReviews

CP000577_GR; Rsph17029_2448.

KEGG

rsh:Rsph17029_2448; -.

CMR

A3PMI4; Rsph17029_2448.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Oxidoreductase; PQQ biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 255`	`255`		`Pyrroloquinoline-quinone synthase.`	`PRO_1000061677`

Sequence information

Length: 255 AA [This is the length of the unprocessed precursor]

Molecular weight: 29090 Da [This is the MW of the unprocessed precursor]

CRC64: 62D2821B96B7EF16 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSLDLSTSLS PARPLESADA MEERLREIGA ARYHDRHPFH HMLHGGELTK GQVQAWALNR 

        70         80         90        100        110        120 
YYYQCTIPVK DAVVISRFRD RATRIEWRHR LEDHDGAEGA EGGIDRWLIL TDGLGLDRAY 

       130        140        150        160        170        180 
VESTDGILPA TRFAVEAYVH FVRDRSPLEA IASCLTELFA PNIHATRISG MLSHYDFINP 

       190        200        210        220        230        240 
TVMAYFQRRL TQAPRDADYA LRYVRDHART PEERAAVCNA LIFKTQVLWT QLDALHHAYV 

       250 
LGHVPPGAFV PEEMR

A3PMI4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools